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dc.creatorGarcía-Junco Clemente, Pabloes
dc.creatorTring, Elainees
dc.creatorRingach, Dario L.es
dc.creatorTrachtenberg, Joshua T.es
dc.date.accessioned2020-09-30T18:48:53Z
dc.date.available2020-09-30T18:48:53Z
dc.date.issued2019-02-26
dc.identifier.citationGarcía-Junco Clemente, P., Tring, E., Ringach, D.L. y Trachtenberg, J.T. (2019). State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. Cell Reports, 26 (9)
dc.identifier.issn2211-1247es
dc.identifier.urihttps://hdl.handle.net/11441/101622
dc.description.abstractBrain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbuminexpressing inhibitory neurons, which exert state-dependent control of network gain and spike patterns, cluster into two stable and functionally distinct subnetworks that are differentially engaged by ascending neuromodulation. One group is excited as a function of increased arousal state; this excitation is driven in part by the increase in cortical norepinephrine that occurs when the locus coeruleus is active. A second group is suppressed during movement when acetylcholine is released into the cortex via projections from the nucleus basalis. These data establish the presence of functionally independent subnetworks of Parvalbumin (PV) cells in the upper layers of the neocortex that are differentially engaged by the ascending reticular activating system.es
dc.description.sponsorshipNIH United States Department of Health & Human Services National Institutes of Health (NIH) - USA R01 EY023871, R01 EY018322, EB022915es
dc.description.sponsorshipJunta de Andalucia P12-CTS-2232es
dc.description.sponsorshipRamon y Cajal programme Spanish Government RYC-2016-19906es
dc.formatapplication/pdfes
dc.format.extent19es
dc.language.isoenges
dc.publisherCell Presses
dc.relation.ispartofCell Reports, 26 (9)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectParvalbumines
dc.subjectInterneuronses
dc.subjectNeocortexes
dc.subjectBraines
dc.subjectAcetylcholinees
dc.subjectNucleus basalises
dc.titleState-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortexes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.projectIDR01 EY023871es
dc.relation.projectIDR01 EY018322es
dc.relation.projectIDEB022915es
dc.relation.projectIDP12-CTS-2232es
dc.relation.projectIDRYC-2016-19906es
dc.relation.publisherversionhttps://doi.org/10.1016/j.celrep. 2019.02.005es
dc.identifier.doi10.1016/j.celrep.2019.02.005es
dc.journaltitleCell Reportses
dc.publication.volumen26es
dc.publication.issue9es

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