dc.creator | García-Junco Clemente, Pablo | es |
dc.creator | Tring, Elaine | es |
dc.creator | Ringach, Dario L. | es |
dc.creator | Trachtenberg, Joshua T. | es |
dc.date.accessioned | 2020-09-30T18:48:53Z | |
dc.date.available | 2020-09-30T18:48:53Z | |
dc.date.issued | 2019-02-26 | |
dc.identifier.citation | García-Junco Clemente, P., Tring, E., Ringach, D.L. y Trachtenberg, J.T. (2019). State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. Cell Reports, 26 (9) | |
dc.identifier.issn | 2211-1247 | es |
dc.identifier.uri | https://hdl.handle.net/11441/101622 | |
dc.description.abstract | Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is
reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory
input from the brain stem and by local inhibition. We find that fast-spiking, parvalbuminexpressing inhibitory neurons, which exert state-dependent control of network gain and spike
patterns, cluster into two stable and functionally distinct subnetworks that are differentially
engaged by ascending neuromodulation. One group is excited as a function of increased arousal
state; this excitation is driven in part by the increase in cortical norepinephrine that occurs when
the locus coeruleus is active. A second group is suppressed during movement when acetylcholine
is released into the cortex via projections from the nucleus basalis. These data establish the
presence of functionally independent subnetworks of Parvalbumin (PV) cells in the upper layers of
the neocortex that are differentially engaged by the ascending reticular activating system. | es |
dc.description.sponsorship | NIH United States Department of Health & Human Services National Institutes of Health (NIH) - USA R01 EY023871, R01 EY018322, EB022915 | es |
dc.description.sponsorship | Junta de Andalucia P12-CTS-2232 | es |
dc.description.sponsorship | Ramon y Cajal programme Spanish Government RYC-2016-19906 | es |
dc.format | application/pdf | es |
dc.format.extent | 19 | es |
dc.language.iso | eng | es |
dc.publisher | Cell Press | es |
dc.relation.ispartof | Cell Reports, 26 (9) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Parvalbumin | es |
dc.subject | Interneurons | es |
dc.subject | Neocortex | es |
dc.subject | Brain | es |
dc.subject | Acetylcholine | es |
dc.subject | Nucleus basalis | es |
dc.title | State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | R01 EY023871 | es |
dc.relation.projectID | R01 EY018322 | es |
dc.relation.projectID | EB022915 | es |
dc.relation.projectID | P12-CTS-2232 | es |
dc.relation.projectID | RYC-2016-19906 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep. 2019.02.005 | es |
dc.identifier.doi | 10.1016/j.celrep.2019.02.005 | es |
dc.journaltitle | Cell Reports | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 9 | es |