Listar Artículos (Fisiología Médica y Biofísica) por título
Mostrando ítems 230-249 de 331
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Prenatal treatment with rapamycin restores enhanced hippocampal mGluR‑LTD and mushroom spine size in a Down’s syndrome mouse model
(BioMed Central Ltd, 2021)Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory ...
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Presenilin/gamma-secretase regulates neurexin processing at synapses
(2011)Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during ...
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Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal
(Frontiers Research Foundation, 2022)Presynaptic Ca2+ regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and ...
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Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
(American Society for Biochemistry and Molecular Biology, 2012-02-03)Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...
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Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells
(1989)The ionic currents of clonal Y-1 adrenocortical cells were studied using the whole-cell variant of the patch-clamp technique. ...
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Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023-03-14)Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ...
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Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons
(BMC, 2019-05-20)Background: Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly ...
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Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis
(Elsevier, 2022-11)The isolation of synaptoneurosomes (SNs) represents a useful means to study synaptic events. However, the size and density ...
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Psychostimulant drugs and neuroplasticity
(MDPI AC, 2011-06-30)Drugs of abuse induce plastic changes in the brain that seem to underlie addictive phenomena. These plastic changes can ...
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R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
(Elsevier, 2020-02-21)Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease ...
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Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules
(2002)Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as ...
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Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
(Elsevier, 2015)Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to ...
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Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric ...
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Redox signaling in acute oxygen sensing
(Elsevier, 2017-04-26)Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
(Nature Publishing Group, 2022)Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. ...
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Regulation of oxygen sensing by ion channels
(2004)O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or ...
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Research facilities and highlights at the Centro Nacional de Aceleradores (CNA)
(Springer, 2021)The Centro Nacional de Aceleradores is a user-oriented accelerator facility in Seville, Spain. Its main facilities are a ...