Listar Artículos (Farmacología) por autor "Calderón Montaño, José Manuel"
Mostrando ítems 1-20 de 30
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5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; López Lázaro, Miguel; Cortés, Felipe; Mateos Cordero, Santiago; Helleday, Thomas (Oxford University Press, 2013)5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ...
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A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; López Lázaro, Miguel (Georg Thieme Verlag, 2013)Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium ...
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Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29
Zbakh, Hanaa; Zubía, Eva; Reyes, Carolina de los; Calderón Montaño, José Manuel; Motilva Sánchez, Virginia (MDPI, 2020)Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The ...
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Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer
Jiménez Alonso, Julio José; Guillén Mancina, Emilio; Calderón Montaño, José Manuel; Jiménez González, Víctor; Díaz Ortega, Patricia; Burgos Morón, Estefanía; López Lázaro, Miguel (MDPI, 2022)New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests ...
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Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma
Jiménez Alonso, Julio José; Guillén Mancina, Emilio; Calderón Montaño, José Manuel; Jiménez González, Víctor; Díaz Ortega, Patricia; Burgos Morón, Estefanía; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with ...
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Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer
Guillén Mancina, Emilio; Jiménez Alonso, Julio José; Calderón Montaño, José Manuel; Jiménez González, Víctor; Díaz Ortega, Patricia; Burgos Morón, Estefanía; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Current treatments for patients with metastatic triple negative breast cancer (TNBC) are generally ineffective. This ...
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Guillén Mancina, Emilio; Mateos Cordero, Santiago; López Lázaro, Miguel (MDPI AG, 2016)Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ...
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Chirality influence on the cytotoxic properties of anionic chiral bis(N-heterocyclic carbene)silver complexes
Carrasco Carrasco, Carlos Jesús; Montilla Ramos, Francisco Javier; Álvarez González, Eleuterio; Calderón Montaño, José Manuel; López Lázaro, Miguel; Galindo del Pozo, Agustín (Elsevier, 2022)Complexes Na3[Ag(NHCR)2], 2a-e and 2b’-c’, where NHCR is a N-heterocyclic carbene of the 2,2′-(1H-2λ3,3λ4-imidazole-1,3-diyl)dicarboxylate ...
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Comment on ‘Quiescence and γH2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase': ouabain and cáncer
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel (Nature Publishing Group, 2013) -
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Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data
López Lázaro, Miguel; Burgos Morón, Estefanía; Tena, J.D.; Sanz, I.; Sainz, J; Calderón Montaño, José Manuel (Biomedical Publisher, 2013)Numerous epidemiological and preclinical studies suggest that flavonoids may play an important role in the decreased risk ...
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
Recio Jiménez, Rocío; Vengut-Climent, Empar; Mouillac, Bernard; Orcel, Hélène; López Lázaro, Miguel; Calderón Montaño, José Manuel; Álvarez González, Eleuterio; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2017)A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ...
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Dichloroacetate, 2-Deoxyglucose and a Hydroalcoholic Extract from the Skin of the Fruit of Solanum melongena (Aubergine) Induce Selective Anticancer Activity against Melanoma Cells
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Martínez Sánchez, Sara María; López Lázaro, Miguel (Biomedical Publisher, 2013)Prognosis of melanoma patients with metastatic disease is very poor. For example, over 95% of melanoma patients with three ...
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Effect of DNA repair deficiencies on the cytotoxicity of resveratrol
López Lázaro, Miguel; Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago (2015)Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial ...
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Evaluating the cancer therapeutic potential of cardiac glycosides
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Maldonado Navas, Dolores; García Domínguez, Irene; López Lázaro, Miguel (Hindawi Publishing Corporation, 2014)Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ...
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Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
Jiménez González, Víctor; Benítez, Guillermo; Pastor Díaz, Julio Enrique; López Lázaro, Miguel; Calderón Montaño, José Manuel (MDPI, 2023)Every year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to ...
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In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside
Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Palo Nieto, Juan Carlos; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and ...
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Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma
Calderón Montaño, José Manuel; Guillén Mancina, Emilio; Jiménez Alonso, Julio José; Jiménez González, Víctor; Burgos Morón, Estefanía; Mate Barrero, Alfonso; Pérez Guerrero, María Concepción; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) ...
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Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents
Zbakh, Hanaa; Zubía, Eva; Reyes, Carolina de los; Calderón Montaño, José Manuel; López Lázaro, Miguel; Motilva Sánchez, Virginia (MDPI, 2020)The anti-inflammatory and anticancer properties of eight meroterpenoids isolated from the brown seaweed Cystoseira usneoides ...
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Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
Henriksson, Sofia; Calderón Montaño, José Manuel; Solvie, Daniel; Warpman Berglund, Ulrika; Helleday, Thomas (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing ...