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Browsing Artículos (Química Orgánica) by Author "Cardona, Francesca"
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Article
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
Matassini, Camilla; Mirabella, Stefania; Goti, Andrea; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Cardona, Francesca (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported ...
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Article
Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
Mirabella, Stefania; D'Adamio, Giampiero; Matassini, Camilla; Goti, Andrea; Delgado, Sandra; Gimeno, Ana; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Šesták, Sergej; Jiménez Barbero, Jesús; Cardona, Francesca (Wiley-Blackwell, 2017)Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...
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Article
Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)
Clemente, Francesca; Matassini, Camilla; Giachetti, Sara; Goti, Andrea; Morrone, Amelia; Martínez Bailén, Macarena; Orta, Sara; Merino, Pedro; Cardona, Francesca (American Chemical Society, 2021)We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with ...
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Article
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019)The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...
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Article
Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors
Davighi, Maria Giulia; Clemente, Francesca; Matassini, Camilla; Martínez Bailén, Macarena; Cardona, Francesca; Goti, Andrea (MDPI, 2020)Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used ...