Artículos (Genética)
Recent Submissions
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Article
Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales
(Nature Research, 2024-07-18)DNA N6-adenine methylation (6mA) has recently gained importance as an epigenetic modification in eukaryotes. Its function ...
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The RNAi Machinery in the Fungus Fusarium fujikuroi Is Not Very Active in Synthetic Medium and Is Related to Transposable Elements
(Multidisciplinary Digital Publishing Institute (MDPI), 2024-05-16)Small RNAS (sRNAs) participate in regulatory RNA interference (RNAi) mechanisms in a wide range of eukaryotic organisms, ...
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EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
(Oxford University Press, 2024-06-24)DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to ...
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Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is ...
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BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...
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Three Genes Involved in Different Signaling Pathways, carS, wcoA, and acyA, Participate in the Regulation of Fusarin Biosynthesis in Fusarium fujikuroi
(MDPI, 2024)The phytopathogenic fungus Fusarium fujikuroi has a rich secondary metabolism which includes the synthesis of very different ...
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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
(CELL PRESS (Elsevier), 2024)During genome duplication, replication forks (RFs) can be stalled by different obstacles or by depletion of replication ...
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Rat1 promotes premature transcription termination at R-loops
(Oxford University Press, 2024-04-24)Certain DNA sequences can adopt a non-B form in the genome that interfere with DNA-templated processes, including ...
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TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
(Nature Research, 2023-11-09)DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 ...
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Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of ...
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
(Cell Press, 2023-08-03)To maintain genome integrity, cells must accurately duplicate their genome and repair DNA lesions when they occur. To ...
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Article
Fusarium photoreceptors
(MDPI, 2023-03-04)Light is an important modulating signal in fungi. Fusarium species stand out as research models for their phytopathogenic ...
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Article
Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
(Nature Publishing Group, 2024)BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is ...
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Article
Transcription-driven DNA supercoiling counteracts H-NS-mediated gene silencing in bacterial chromatin.
(Nature Research, 2024-03-30)In all living cells, genomic DNA is compacted through interactions with dedicated proteins and/or the formation of plectonemic ...
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Analysis of Salmonella lineage-specific traits upon cell sorting
(Frontiers Media SA, 2023-03-29)Microbial cell individuality is receiving increasing interest in the scientific community. Individual cells within clonal ...
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Article
Specificities and Redundancies in the NEL Family of Bacterial E3 Ubiquitin Ligases of Salmonella Enterica Serovar Typhimurium
(Frontiers Media, 2024)Salmonella enterica serovar Typhimurium expresses two type III secretion systems, T3SS1 and T3SS2, which are encoded in ...
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Article
Bioavailability and provitamin A activity of neurosporaxanthin in mice
(Nature Publishing Group, 2023-10-20)Various species of ascomycete fungi synthesize the carboxylic carotenoid neurosporaxanthin. The unique chemical structure ...
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Article
Lack of reelin modifies the gene expression in the small intestine of mice
(Springer Nature, 2012)We recently demonstrated that the mucosa of the small intestine of the rat expresses reelin and some components of its ...
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Article
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
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Article
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...