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Mostrando ítems 111-120 de 452
Artículo
TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage
(American Society for Biochemistry and Molecular Biology, 2011-01-07)
Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5′-phosphotyrosyl bond. Although these intermediates are normally transient, they ...
Artículo
Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
(Oxford University Press, 2018)
The contribution of most ribosomal proteins to ribo- some synthesis has been quite well analysed in Sac- charomyces cerevisiae . However, few yeast riboso- mal proteins still await characterization. Herein, we show ...
Artículo
The COP9 signalosome is vital for timely repair of DNA double-strand breaks
(Oxford University Press, 2015)
The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response is the ATM protein kinase. We discovered that the COP9 signalosome (CSN) is a crucial player in ...
Artículo
Non‐Canonical Replication Initiation: You’re Fired!
(MDPI, 2017)
The division of prokaryotic and eukaryotic cells produces two cells that inherit a perfect copy of the genetic material originally derived from the mother cell. The initiation of canonical DNA replication must be coordinated ...
Artículo
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)
DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads to DNA damage and genomic instability. Replication stress is commonly associated with slow and stalled ...
Artículo
Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella
(National Academy of Sciences, 2015)
Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria. Although ...
Artículo
Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice
(Oxford University Press, 2015)
DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation ...
Artículo
Functional Characterization of Lysophosphatidylcholine: Acyl-CoA Acyltransferase Genes From Sunflower (Helianthus annuus L.)
(MDPI, 2020)
Lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) is an evolutionarily conserved key enzyme in the Lands cycle that catalyzes acylation of lysophosphatidylcholine (LPC) to produce phosphatidylcholine (PC), the ...
Artículo
Microscopic and transcriptome analyses of early colonization of tomato roots by "Trichoderma harzianum".
(Institut d´Estudis Catalans, 2007)
The capacity of the fungus Trichoderma harzianum CECT 2413 to colonize roots and stimulate plant growth was analyzed. Tobacco seedlings (Nicotiana benthamiana) transferred to Petri dishes inoculated with T. harzianum ...
Artículo
Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae
(American Society for Microbiology, 2023)
It is unclear how gene order within the chromosome influences genome evolution. Bacteria cluster transcription and translation genes close to the replication origin (oriC). In Vibrio cholerae, relocation of s10-spc-α locus ...