Artículo
Targeted multifunctional tannic acid nanoparticles
Autor/es | Aguilera Velázquez, José Raúl
Venegas, V. Oliva, J.M. Sayagués de Vega, María Jesús Miguel Rodríguez, Manuel de ![]() ![]() ![]() ![]() ![]() ![]() ![]() Sánchez-Alcazar, José Antonio Zaderenko Partida, Ana-Paula |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2016 |
Fecha de depósito | 2021-04-26 |
Publicado en |
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Resumen | Tannic acid (TA) has multiple effects against cancer, being especially promising in those types that
overexpress the epidermal growth factor receptor (EGFR), as TA modulates its activation and
downstream signaling pathways, ... Tannic acid (TA) has multiple effects against cancer, being especially promising in those types that overexpress the epidermal growth factor receptor (EGFR), as TA modulates its activation and downstream signaling pathways, triggering apoptosis. Nonetheless, despite the important role of this receptor in the pathogenesis and progression of a wide variety of tumors, no TA systems targeted to this receptor have been described yet. In this work, we synthesize, characterize by physico-chemical techniques and study the cytotoxic effect and cell uptake of TA nanoparticles targeted to EGFR in both tumoral and normal human skin cells. Our nanoparticles exhibited an extremely high entrapment efficiency, and were only toxic for the tumoral cells. The uptake assay demonstrated that nanoparticles are able to enter the cells through a receptor-mediated mechanism. Furthermore, we have included fluorescent markers in these nanoparticles to combine imaging and therapeutic applications, thus building effectively a multifunctional tool for biomedicine. |
Cita | Aguilera, J.R., Venegas, V., Oliva, J.M., Sayagués de Vega, M.J., de Miguel, M., Sánchez-Alcazar, J.A. y Zaderenko Partida, A-P. (2016). Targeted multifunctional tannic acid nanoparticles. RSC Advances, 6 (9), 7279-7287. |
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