dc.creator | Aguilera Velázquez, José Raúl | es |
dc.creator | Venegas, V. | es |
dc.creator | Oliva, J.M. | es |
dc.creator | Sayagués de Vega, María Jesús | es |
dc.creator | Miguel Rodríguez, Manuel de | es |
dc.creator | Sánchez-Alcazar, José Antonio | es |
dc.creator | Zaderenko Partida, Ana-Paula | es |
dc.date.accessioned | 2021-04-26T15:42:45Z | |
dc.date.available | 2021-04-26T15:42:45Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Aguilera, J.R., Venegas, V., Oliva, J.M., Sayagués de Vega, M.J., de Miguel, M., Sánchez-Alcazar, J.A. y Zaderenko Partida, A-P. (2016). Targeted multifunctional tannic acid nanoparticles. RSC Advances, 6 (9), 7279-7287. | |
dc.identifier.issn | 2046-2069 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/107847 | |
dc.description.abstract | Tannic acid (TA) has multiple effects against cancer, being especially promising in those types that
overexpress the epidermal growth factor receptor (EGFR), as TA modulates its activation and
downstream signaling pathways, triggering apoptosis. Nonetheless, despite the important role of this
receptor in the pathogenesis and progression of a wide variety of tumors, no TA systems targeted to this
receptor have been described yet. In this work, we synthesize, characterize by physico-chemical
techniques and study the cytotoxic effect and cell uptake of TA nanoparticles targeted to EGFR in both
tumoral and normal human skin cells. Our nanoparticles exhibited an extremely high entrapment
efficiency, and were only toxic for the tumoral cells. The uptake assay demonstrated that nanoparticles
are able to enter the cells through a receptor-mediated mechanism. Furthermore, we have included
fluorescent markers in these nanoparticles to combine imaging and therapeutic applications, thus
building effectively a multifunctional tool for biomedicine. | es |
dc.description.sponsorship | Junta de Andalucía (Proyecto de Investigación de Excelencia P10-FQM-6615 and PAIDI FQM319) | es |
dc.description.sponsorship | Fondo Europeo de Desarrollo Regional (FEDER-Unión Europea) | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad, Gobierno de España (Proyecto de Excelencia CTQ2013-48396-P) | es |
dc.description.sponsorship | Junta de Andalucía (P10- FQM-06615) | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | The Royal Society of Chemistry | es |
dc.relation.ispartof | RSC Advances, 6 (9), 7279-7287. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Tannic acid (TA) | es |
dc.subject | EGFR | es |
dc.subject | Cancer | es |
dc.title | Targeted multifunctional tannic acid nanoparticles | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.contributor.sponsorship | This work was supported by Junta de Andaluc´ıa (Proyecto de
Investigaci´on de Excelencia P10-FQM-6615 and PAIDI FQM319), Fondo Europeo de Desarrollo Regional (FEDER-Uni´on
Europea) and Ministerio de Econom´ıa y Competitividad,
Gobierno de Espana (Proyecto de Excelencia CTQ2013-48396-P). ˜
Jos´e M. Oliva-Montero is grateful to the Junta de Andaluc´ıa (P10-
FQM-06615) for his pre-doctoral fellowship. | |
dc.identifier.doi | 10.1039/c5ra19405a | es |
dc.journaltitle | RSC Advances | es |
dc.publication.volumen | 6 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 7279 | es |
dc.publication.endPage | 7287 | es |