Artículo
An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia
Autor/es | Platero-Luengo, Aida
![]() ![]() ![]() ![]() ![]() ![]() ![]() González-Granero, Susana Durán Romero, Rocío Díaz Castro, Blanca Piruat Palomo, José Ignacio García-Verdugo, José Manuel Pardal Redondo, Ricardo ![]() ![]() ![]() ![]() ![]() ![]() ![]() López Barneo, José ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Fecha de publicación | 2014-01-16 |
Fecha de depósito | 2021-04-23 |
Publicado en |
|
Resumen | Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells ... Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells is coupled with changes in physiological demand is poorly understood. Here, we show that hypoxia does not affect CB NSC proliferation directly. Rather, mature glomus cells expressing endothelin-1, the O2-sensing elements in the CB that secrete neurotransmitters in response to hypoxia, establish abundant synaptic-like contacts with stem cells, which express endothelin receptors, and instruct their growth. Inhibition of glomus cell transmitter release or their selective destruction markedly diminishes CB cell growth during hypoxia, showing that CB NSCs are under the direct "synaptic" control of the mature O2-sensitive cells. Thus, glomus cells not only acutely activate the respiratory center but also induce NSC-dependent CB hypertrophy necessary for acclimatization to chronic hypoxemia. |
Cita | Platero-Luengo, A., González-Granero, S., Durán Romero, R., Díaz Castro, B., Piruat Palomo, J.I., García-Verdugo, J.M.,...,López Barneo, J. (2014). An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia. Cell, 156 (1–2), 291-303. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
An O-2-sensitive glomus cell-stem ... | 3.472Mb | ![]() | Ver/ | |