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dc.creatorLorenzo, Petra I.es
dc.creatorMartín Montalvo, Alejandroes
dc.creatorCobo Vuilleumier, Nadiaes
dc.creatorGauthier, Benoit R.es
dc.date.accessioned2020-10-19T17:50:47Z
dc.date.available2020-10-19T17:50:47Z
dc.date.issued2019
dc.identifier.citationLorenzo, P.I., Martín Montalvo, A., Cobo Vuilleumier, N. y Gauthier, B.R. (2019). Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus. International Journal of Molecular Sciences, 20 (24), 6171-.
dc.identifier.issn1661-6596es
dc.identifier.issn1422-0067es
dc.identifier.urihttps://hdl.handle.net/11441/102048
dc.description.abstractGestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late pregnancy, is currently one of the most common complications affecting pregnancy. The polygenic nature of GDM, together with the interplay between different genetic variants with nutritional and environmental factors has hindered the full understanding of the etiology of this disease. However, an important genetic overlap has been found with type 2 diabetes mellitus (T2DM) and, as in the case of T2DM, most of the identified loci are associated with β-cell function. Early detection of GDM and adequate interventions to control the maternal glycemia are necessary to avoid the adverse outcomes for both the mother and the offspring. The in utero exposure to the diabetic milieu predispose these children for future diseases, among them T2DM, originating a vicious circle implicated in the increased prevalence of both GDM and T2DM. The involvement of inflammatory processes in the development of GDM highlights the importance of pancreatic β-cell factors able to favor the adaptation processes required during gestation, concomitantly with the protection of the islets from an inflammatory milieu. In this regard, two members of the Pax family of transcription factors, PAX4 and PAX8, together with the chromatin remodeler factor HMG20A, have gained great relevance due to their involvement in β-cell mass adaptation together with their anti-inflammatory properties. Mutations in these factors have been associated with GDM, highlighting these as novel candidates for genetic screening analysis in the identification of women at risk of developing GDM.es
dc.description.sponsorshipJunta de Andalucía PI-0727-2010, PI-0085-2013, P10.CTS.6359es
dc.description.sponsorshipMinisterio de Economía y Competitividad PI10/00871, PI13/00593es
dc.formatapplication/pdfes
dc.format.extent19 p.es
dc.language.isoenges
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.relation.ispartofInternational Journal of Molecular Sciences, 20 (24), 6171-.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFetal growth alterationes
dc.subjectGestational diabeteses
dc.subjectGestational hypertensiones
dc.subjectHMG20Aes
dc.subjectInflammationes
dc.subjectPAX4es
dc.subjectPAX8es
dc.subjectPregnancyes
dc.titleMolecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellituses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.projectIDPI-0727-2010es
dc.relation.projectIDPI-0085-2013es
dc.relation.projectIDP10.CTS.6359es
dc.relation.projectIDPI10/00871es
dc.relation.projectIDPI13/00593es
dc.relation.projectIDCP14/00105es
dc.relation.projectIDPI18/01590es
dc.relation.projectIDPI15/00134es
dc.relation.publisherversionhttps://doi.org/10.3390/ijms20246171es
dc.identifier.doi10.3390/ijms20246171es
dc.journaltitleInternational Journal of Molecular Scienceses
dc.publication.volumen20es
dc.publication.issue24es
dc.publication.initialPage6171es
dc.contributor.funderInstituto de Salud Carlos III CP14/00105, PI18/01590, PI15/00134es

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