Artículo
Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii
Autor/es | Cebrero-Cangueiro, T.
Nordmann, P. Carretero-Ledesma, M. Pachón Díaz, Jerónimo Pachón Ibáñez, María Eugenia |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-10-10 |
Publicado en |
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Resumen | Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus mero penem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.
Methods: ... Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus mero penem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58. Methods: An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. baumannii clinical isolates. The efficacies of the carbapenems in monotherapy and in combination were tested. Results: Meropenem was better than imipenem in mice infected with either of the carbapenem-resistant A. baumannii (CRAb) strains. The combination of meropenem plus imipenem significantly improved the clear ance of CRAbs from spleen compared with non-treated groups. The carbapenem-containing combination was better than imipenem for treating mice infected with both carbapenemase producers. In blood, the carbapenem combination significantly decreased the bacterial load of the OXA-23 producers compared with imipenem or meropenem used in monotherapy. Conclusions: These results suggest that dual carbapenem combination could be an option for the treatment of infections due to carbapenemase-producing A. baumannii such as OXA-23 and OXA-58 producers. |
Cita | Cebrero-Cangueiro, T., Nordmann, P., Carretero-Ledesma, M., Pachón Díaz, J. y Pachón Ibáñez, M.E. (2021). Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy, 76 (3), 680-683. https://doi.org/10.1093/jac/dkaa487. |
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