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Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii
dc.creator | Cebrero-Cangueiro, T. | es |
dc.creator | Nordmann, P. | es |
dc.creator | Carretero-Ledesma, M. | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.creator | Pachón Ibáñez, María Eugenia | es |
dc.date.accessioned | 2022-10-10T14:02:36Z | |
dc.date.available | 2022-10-10T14:02:36Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Cebrero-Cangueiro, T., Nordmann, P., Carretero-Ledesma, M., Pachón Díaz, J. y Pachón Ibáñez, M.E. (2021). Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy, 76 (3), 680-683. https://doi.org/10.1093/jac/dkaa487. | |
dc.identifier.issn | 0040-6376 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137766 | |
dc.description.abstract | Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus mero penem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58. Methods: An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. baumannii clinical isolates. The efficacies of the carbapenems in monotherapy and in combination were tested. Results: Meropenem was better than imipenem in mice infected with either of the carbapenem-resistant A. baumannii (CRAb) strains. The combination of meropenem plus imipenem significantly improved the clear ance of CRAbs from spleen compared with non-treated groups. The carbapenem-containing combination was better than imipenem for treating mice infected with both carbapenemase producers. In blood, the carbapenem combination significantly decreased the bacterial load of the OXA-23 producers compared with imipenem or meropenem used in monotherapy. Conclusions: These results suggest that dual carbapenem combination could be an option for the treatment of infections due to carbapenemase-producing A. baumannii such as OXA-23 and OXA-58 producers. | es |
dc.format | application/pdf | es |
dc.format.extent | 4 p. | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | Journal of Antimicrobial Chemotherapy, 76 (3), 680-683. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sepsis | es |
dc.subject | Carbapenem | es |
dc.subject | Drug clearance | es |
dc.title | Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://academic.oup.com/jac/article/76/3/680/5998969 | es |
dc.identifier.doi | 10.1093/jac/dkaa487 | es |
dc.journaltitle | Journal of Antimicrobial Chemotherapy | es |
dc.publication.volumen | 76 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 680 | es |
dc.publication.endPage | 683 | es |
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