Artículo
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
Autor/es | Espinosa Oliva, Ana María
García Miranda, Pablo Alonso Bellido, Isabel María Carvajal Vázquez, Ana Eloisa González Rodríguez, Melania Carrillo Jiménez, Alejandro García Domínguez, Irene Vázquez Carretero, María Dolores García Revilla, Juan Santiago Pavón, Martiniano Peral Rubio, María José Venero Recio, José Luis Martínez de Pablos, Rocío |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-07-14 |
Publicado en |
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Resumen | Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In ... Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral inflammation, especially the originated in the colon, is emerging as a predisposing factor for suffering this disease. We have largely studied the pleiotropic roles of galectin-3 in driving microglia-associated immune responses. However, studies aimed at elucidating the role of galectin-3 in peripheral inflammation in terms of microglia polarization are lacking. To achieve this, we have evaluated the effect of galectin-3 deletion in two different models of acute peripheral inflammation: intraperitoneal injection of lipopolysaccharide or gut inflammation induced by oral administration of dextran sodium sulfate. We found that under peripheral inflammation the number of microglial cells and the expression levels of pro-inflammatory mediators take place specifically in the dopaminergic system, thus supporting causative links between Parkinson’s disease and peripheral inflammation. Absence of galectin-3 highly reduced neuroinflammation in both models, suggesting an important central regulatory role of galectin-3 in driving microglial activation provoked by the peripheral inflammation. Thus, modulation of galectin-3 function emerges as a promising strategy to minimize undesired microglia polarization states. |
Agencias financiadoras | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía |
Identificador del proyecto | RTI-2018-098830-B-I00
P18-RT-1372 US-1264806 CTS-5884 |
Cita | Espinosa Oliva, A.M., García Miranda, P., Alonso Bellido, I.M., Carvajal Vázquez, A.E., González Rodríguez, M., Carrillo Jiménez, A.,...,Martínez de Pablos, R. (2021). Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon. Frontiers in Pharmacology, 12, 706439. |
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