Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Perfil del autor: Martínez de Pablos, Rocío
Datos institucionales
| Nombre | Martínez de Pablos, Rocío |
| Departamento | Bioquímica y Biología Molecular |
| Área de conocimiento | Bioquímica y Biología Molecular |
| Categoría profesional | Catedrática de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
40
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Nº visitas
15102
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Nº descargas
28215
| Publicaciones |
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Artículo
 Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response
(Springer Nature, 2024)
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in ... |
Artículo
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous ... |
Artículo
Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection
(Elsevier, 2023)
Background Blood OX40-expressing CD4 T-cells from antiretroviral (ART)-treated people living with HIV (PWH) were found to ... |
Artículo
Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Nemaline myopathy (NM) is one of the most common forms of congenital myopathy and it is identified by the presence of ... |
Trabajo Fin de Grado
Influencia de la alimentación en el desarrollo de enfermedades neurodegenerativas
(2023)
Las enfermedades neurodegenerativas son enfermedades de carácter progresivo y de diversa naturaleza cuya prevalencia está ... |
Artículo
 Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
(Elsevier, 2023)
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ... |
Trabajo Fin de Grado
Microbiota y enfermedades neurodegenerativas: Efectos reales de probióticos y prebióticos
(2022)
El estudio de la microbiota es un campo en investigación que promete grandes avances en el tratamiento de enfermedades. ... |
| Artículo |
Artículo
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ... |
Artículo
Inflammatory Animal Models of Parkinson's Disease
(IOS Press, 2022)
Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis ... |
Artículo
Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ... |
Artículo
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ... |
Artículo
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ... |
Trabajo Fin de Grado
Efectos del estrés sobre el sistema inmune
(2021)
El estrés se puede definir de forma global como el conjunto de reacciones fisiológicas que preparan al organismo para dar ... |
Artículo
Editorial: Neurodegeneration: From Genetics to Molecules (Part II)
(Frontiers Media, 2021)
Among non-transmissible chronic diseases, neurodegenerative complications have become a big challenge in public health. ... |
Artículo
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)
Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ... |
Artículo
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
(Springer Nature, 2021)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ... |
Trabajo Fin de Grado
Efectos del ejercicio físico sobre el sistema inmune
(2020)
El sistema inmune (SI) es el principal encargado de mantener la homeostasis del organismo frente a amenazas externas y ... |
Trabajo Fin de Grado
Intolerancia a la lactosa y efectos en la microbiota
(2020)
La intolerancia a la lactosa es una enfermedad provocada por la mala absorción del disacárido lactosa y que produce ... |
Tesis Doctoral
Implicación de las caspasas-3 y -8 en el trastorno del espectro autista y la enfermedad de Parkinson
(2020)
El trastorno del espectro autista (TEA) y la enfermedad de Parkinson (EP) son dos desórdenes neurológicos que presentan ... |
Artículo
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
(MDPI, 2020)
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as ... |
Artículo
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ... |
Tesis Doctoral
Metformin treatment decreases microglial activation in the in vivo lps model of parkinson's disease.
(2018)
Metformin is a widely used oral antidiabetic drug with known anti-inflammatory properties due to its action on AMP kinase. ... |
Artículo
Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation
(Frontiers Media S.A., 2018)
Neuroinflammation is a pathological feature of quite a number of Central Nervous System diseases such as Alzheimer and ... |
Trabajo Fin de Grado
Influencia de la alimentación en el correcto funcionamiento del sistema inmune
(2018)
En base a la creciente incidencia de ciertas enfermedades autoinmunes y alergias alimentarias y a la coincidencia de este ... |
Artículo
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ... |
Artículo
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
(Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ... |
Artículo
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
(BioMed Central, 2016)
Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells ... |
Artículo
Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus
(Elsevier, 2016)
The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and ... |
Artículo
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and ... |
Artículo
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
(rontiers Research Foundation, 2015)
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the ... |
Tesis Doctoral
Efecto del tratamiento con metformina en el sistema dopaminérgico nigroestriado: posible implicación en la enfermedad de parkinson.
(2014)
La enfermedad de Parkinson (EP) es un desorden relacionado con la edad caracterizado por la degeneración progresiva de las ... |
Artículo
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation
(BioMed Central, 2014)
Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and ... |
Artículo
Implantación del Plan de orientación y acción tutorial en la Facultad de Farmacia de la Universidad de Sevilla
(Universidad de Granada: Facultad de Farmacia, 2014)
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Artículo
Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)
Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s ... |
Artículo
Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)
We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ... |
Artículo
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of ... |
| Tesis Doctoral |
Artículo
Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex
(Society for Neuroscience, 2006)
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because ... |
Tesis Doctoral
Implicación de la dopamina en los procesos degenerativos del sistema nigroestraido
(2005)
Nuestro grupo lleva años estudiando los mecanismos de degeneración del sistema dopaminérgico nigroestriado que podrían ... |