Author profile: Venero Recio, José Luis
Institutional data
| Name | Venero Recio, José Luis |
| Department | Bioquímica y Biología Molecular |
| Knowledge area | Bioquímica y Biología Molecular |
| Professional category | Catedrático de Universidad |
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Statistics
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No. publications
59
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No. visits
11045
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No. downloads
18043
| Publications |
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Article
 Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ... |
Article
Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
(Elsevier, 2023)
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have ... |
Article
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
(Nature Research, 2023)
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ... |
PhD Thesis
Caracterización del modelo condicional neuronal de caspasa 3 en condiciones fisiológicas y patológicas
(2022)
La caspasa 3 (casp 3) es una proteasa ampliamente conocida por su papel clave como mediadora en la apoptosis neuronal. En ... |
PhD Thesis
Papeles no apoptóticos de las caspasas en la neurogénesis hipocampal y el desarrollo embrionario de la microglía
(2022)
Debido al aumento de la esperanza de vida, existe cada vez una mayor prevalencia de enfermedades neurodegerativas que, ... |
Article
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ... |
Article
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
(Springer Nature, 2022)
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ... |
Article
Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
(Springer, 2022)
Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ... |
Article
Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ... |
Article
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ... |
Article
Inflammatory Animal Models of Parkinson's Disease
(IOS Press, 2022)
Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis ... |
Article
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ... |
Final Degree Project
Apoe y enfermedad de Alzheimer
(2021)
La Enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa que afecta a un creciente número de personas en todo ... |
Article
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients
(Frontiers Media S.A., 2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease ... |
Article
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)
Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ... |
PhD Thesis
Implicación de las caspasas-3 y -8 en el trastorno del espectro autista y la enfermedad de Parkinson
(2020)
El trastorno del espectro autista (TEA) y la enfermedad de Parkinson (EP) son dos desórdenes neurológicos que presentan ... |
Article
Microglia: Agents of the CNS Pro-Inflammatory Response
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative ... |
Article
The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond Movement
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where ... |
Article
Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider
(Frontiers Media, 2020)
COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any ... |
Article
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
(MDPI, 2020)
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as ... |
PhD Thesis
The role of Galectin-3 in the pathogenesis of Parkinson's Disease
(2019)
En 1817, James Parkinson describió por primera vez un conjunto de síntomas motores en el ensayo titulado “Shaking Palsy” ... |
Final Degree Project
Papel de la microglía en la patogenia de enfermedades neurodegenerativas
(2019)
La microglía son las células del sistema nervioso central encargadas del mantenimiento de la inmunidad ... |
Final Degree Project
Papel de la microglía en la enfermedad de Alzheimer
(2019)
Microglia have always been thought as the central nervous system security guard. Their functions as sensor, housekeeper ... |
Article
TET2 Regulates the Neuroinflammatory Response in Microglia
(Elsevier, 2019)
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ... |
Article
Magnetofection as a new tool to study microglia biology
(Medknow Publications, 2019)
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Article
Microglial subtypes: diversity within the microglial community
(EMBO Press, 2019)
Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill ... |
Article
Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ... |
Article
Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent ... |
PhD Thesis
Papel de la galectina-3 en la respuesta inmune y en la pérdida neuronal asociada a un modelo murino de daño cerebral traumático.
(2018)
La lesión cerebral traumática (TBI) es actualmente una causa importante de muerte y discapacidad en la sociedad occidental, ... |
Article
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ... |
Article
Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation
(Frontiers Media, 2018)
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, ... |
Article
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
(Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ... |
Article
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation
(Springer Nature, 2018)
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate ... |
Final Degree Project
Presente y futuro de la inmunoterapia en cáncer
(2017)
El cáncer es una de las causas principales de muerte en todo el mundo. La falta de tratamientos en la actualidad, se debe ... |
Article
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
(Nature, 2017)
Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an ... |
Article
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
(BioMed Central, 2016)
Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells ... |
Article
PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity. (Erratum) Aging, 2015; 7(9): 629‐647.
(Impact Journals, 2016)
In this article, the additional author Aine Brigette Henley is added to this manuscript: http://www.impactaging.com/papers/v7/n9/pdf/100790.pdf. |
Article
Caspase-8 inhibition represses initial human monocyte activation in septic shock model
(Impact Journals, 2016)
In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic ... |
Final Degree Project
Bases moleculares de los inflamasomas: implicaciones patológicas
(2016)
Esta revisión bibliográfica llevada a cabo, nos acerca hacia varios conceptos relativos a diferentes mecanismos que se ... |
PhD Thesis
A dual tool. The role of the ripoptosome in phagocytic cell activation and differentiation
(2015)
El término ripoptosoma hace referencia a la plataforma molecular que contiene, entre otras, dos proteínas implicadas en ... |
Article
PGC-1alfa controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
(Impact Journals LLC, 2015)
Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative ... |
Article
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and ... |
Article
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
(rontiers Research Foundation, 2015)
This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the ... |
Article
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
(Impact Journals, LLC, 2015)
Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ... |
Article
PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
(Impact Journals, 2015)
Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative ... |
Article
Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
(2015)
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory ... |
Article
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation
(BioMed Central, 2014)
Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement disorders and ... |
Article
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia
(Nature Publishing Group, 2014)
The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity ... |
Article
Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)
Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s ... |
Article
The role of Galectin-3 in α-synuclein-induced microglial activation
(BioMed Central, 2014)
Background: Parkinson ’ s disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology ... |
Article
Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)
We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ... |
Article
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
(Elsevier, 2011)
We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ... |
Article
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of ... |
| PhD Thesis |
Article
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
(American Society for Microbiology, 2008)
The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ... |
Article
Mitochondrial toxins and neurodegenerative diseases
(IMR Press, 2007)
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in ... |
Article
Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex
(Society for Neuroscience, 2006)
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because ... |
| PhD Thesis |
| PhD Thesis |