Article
Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
Author/s | Burguillos García, Miguel Ángel
![]() ![]() ![]() ![]() ![]() ![]() ![]() Svensson, Martina Schulte, Tim Boza Serrano, Antonio ![]() ![]() ![]() ![]() ![]() García Quintanilla, Alberto ![]() ![]() ![]() ![]() ![]() ![]() Kavanagh, Edel T. Santiago Pavón, Martiniano ![]() ![]() ![]() ![]() ![]() ![]() ![]() Viceconte, Nikenza Oliva Martín, María José Osman, Ahmed Mohamed Salomonsson, Emma Amar, Lahouari Persson, Annette Blomgren, Klas Achour, Adnane Englund, Elisabet Leffler, Hakon Venero Recio, José Luis ![]() ![]() ![]() ![]() ![]() ![]() ![]() Joseph, Bertrand Deierborg, Tomas |
Department | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Date | 2015 |
Published in |
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Abstract | Inflammatory response induced by microglia plays
a critical role in the demise of neuronal populations
in neuroinflammatory diseases. Although the role of
toll-like receptor 4 (TLR4) in microglia’s inflammatory
response ... Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia’s inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent- TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain |
Citation | Burguillos García, M.Á., Svensson, M., Schulte, T., Boza Serrano, A., García Quintanilla, A., Kavanagh, E.T.,...,Deierborg, T. (2015). Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation. Cell Reports, 10 (9), 1626-1639. |
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