Perfil del autor: Chávez de Diego, Sebastián
Datos institucionales
| Nombre | Chávez de Diego, Sebastián |
| Departamento | Genética |
| Área de conocimiento | Genética |
| Categoría profesional | Catedrático de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
61
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Nº visitas
8569
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Nº descargas
11120
| Publicaciones |
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Tesis Doctoral
 Molecular bases of proliferative heterogeneity in Saccharomyces cerevisiae
(2023)
Proliferative heterogeneity has been widely described in clonal cultures, but the mechanisms underlying this phenomenon ... |
Artículo
Enhanced Gene Regulation by Cooperation between mRNA Decay and Gene Transcription
(Elsevier, 2023)
It has become increasingly clear in the last few years that gene expression in eukaryotes is not a linear process from ... |
Artículo
Nucleo-cytoplasmic Shuttling of RNA-binding Factors: mRNA Buffering and Beyond
(Elsevier, 2022)
Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under ... |
Artículo
The Total mRNA Concentration Buffering System in Yeast is Global Rather than Gene-specific
(Cold Spring Harbor Laboratory Press, 2021)
Gene expression in eukaryotes does not follow a linear process from transcription to translation and mRNA degradation. ... |
Artículo
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration
(Taylor & Francis, 2021)
mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the ... |
Artículo
Cell Volume Homeostatically Controls the rDNA Repeat Copy Number and rRNA Synthesis Rate in Yeast
(Public Library of Science, 2021)
The adjustment of transcription and translation rates to the changing needs of cells is of utmost importance for their ... |
Artículo
 Human prefoldin modulates co-transcriptional pre-mRNA splicing
(Oxford University Press, 2021)
Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the ... |
Artículo
Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer
(2020)
Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes ... |
Artículo
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4
(Oxford University Press, 2019)
Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex ... |
Tesis Doctoral
Contribución de prefoldina a la expresión génica en células humanas
(2019)
La prefoldina es una cochaperona que está presente en todos los organismos eucarióticos. Es conocida principalmente por ... |
Artículo
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1
(eLife Sciences, 2018)
Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source ... |
Tesis Doctoral
The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay.
(2018)
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the ... |
Artículo
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning
(BioMed Central, 2017)
TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the ... |
Artículo
Asymmetric cell division requires specific mechanisms for adjusting global transcription
(Oxford University Press, 2017)
Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric ... |
Artículo
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
(Oxford University Press, 2017)
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA ... |
Artículo
Regulation of transcription elongation in response to osmostress
(Public Library of Science, 2017)
Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase ... |
Tesis Doctoral
Microbial analysis by microencapsulation and its application to study proliferation heterogeneity
(2016)
El interés hacia la producción de microcápsulas ha aumentado en los últimos años significativamente debido a la gran ... |
| Tesis Doctoral |
Artículo
Growth rate controls mRNA turnover in steady and non-steady states
(Taylor & Francis, 2016)
Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different ... |
Artículo
The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
(Oxford University Press, 2016)
We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription ... |
Artículo
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
(Oxford University Press, 2015)
Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important ... |
Artículo
Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle
(Oxford University Press, 2015)
The particular behaviour of eukaryotic RNA polymerases along different gene regions and amongst distinct gene functional ... |
Artículo
Flow Cytometry of Microencapsulated Colonies for Genetics Analysis of Filamentous Fungi
(Genetics Society of America:, 2014)
The analysis of filamentous fungi by flow cytometry has been impossible to date due to their filamentous nature and size. ... |
Artículo
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
(Frontiers Media, 2014)
The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component ... |
Artículo
Nuclear functions of prefoldin
(The Royal Society, 2014)
Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its ... |
Artículo
The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription
(Oxford University Press, 2014)
Bud27, the yeast orthologue of human URI/RMP, is a member of the prefoldin-like family of ATPindependent molecular chaperones. ... |
Artículo
Balanced production of ribosome components is required for proper G/S transition in saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology Inc., 2013)
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| Artículo |
Artículo
The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation
(Public Library of Science, 2013)
Transcriptional elongation requires the concerted action of several factors that allow RNA polymerase II to advance through ... |
Artículo
Genome-wide studies of mRNA synthesis and degradation in eukaryotes
(Elsevier BV, 2012)
In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing ... |
| Artículo |
Artículo
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
(Oxford University Press, 2012)
Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume ... |
Artículo
One step back before moving forward: regulation of transcription elongation by arrest and backtracking
(Wiley-Blackwell, 2012)
RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. ... |
Tesis Doctoral
Una conexión entre el complejo FACT y progresión de la célula Saccharomyces cerevisiae
(2012)
The FACT complex is an essential component of eukaryotic ce ... lls able to modify the chromatin structure allowing ... |
Artículo
Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency
(American Society for Microbiology, 2011)
The establishment of a stable reservoir of latently infected cells allows HIV to persist in the host. Usually, HIV infection ... |
Artículo
Application of flow focusing to the break-up of a magnetite suspension jet for the production of paramagnetic microparticles
(2011)
Paramagnetic particles offer an extensive improvement in the magnetic separation or purification of a wide variety of ... |
| Artículo |
Artículo
FACT Prevents the Accumulation of Free Histones Evicted from Transcribed Chromatin and a Subsequent Cell Cycle Delay in G1
(Public Library of Science, 2010)
The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants ... |
| Artículo |
Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ... |
Artículo
Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes
(EMBO Press, 2009)
For efficient transcription, RNA PolII must overcome the presence of nucleosomes. The p38-related MAPK Hog1 is an important ... |
Artículo
Regulon-Specific Control of Transcription Elongation across the Yeast Genome
(Public Library of Science, 2009)
Transcription elongation by RNA polymerase II was often considered an invariant non-regulated process. However, genome-wide ... |
Artículo
Yeast Genetic Analysis Reveals the Involvement of Chromatin Reassembly Factors in Repressing HIV-1 Basal Transcription
(Public Library of Science, 2009)
Rebound of HIV viremia after interruption of anti-retroviral therapy is due to the small population of CD4+ T cells that ... |
Patente. Invención
Metodo para el ensayo de la expresion del genoma de una muestra biologica y kit para su realizacion.
(Oficina Española de Patentes y Marcas , 2008)
Método para el ensayo de la expresión del genoma de una muestra biológica y kit para su realización.El objeto de la presente ... |
Patente. Invención
Procedimiento de expresion regulada de genes en celulas eucarioticas y elementos para su realizacion
(Oficina Española de Patentes y Marcas , 2008)
Procedimiento de expresión regulada de genes en células eucarióticas y elementos para su realización. La presente invención ... |
Patente. Invención
Procedimiento de preparación de partículas de tamaño micro y nanométrico con productos lábiles y partículas obtenidas
(Universidad de Sevilla, 2008)
Procedimiento de preparación de partículas de tamaño micro y nanométrico con productos lábiles y partículas obtenidas. La ... |
Tesis Doctoral
Genómica funcional de la elongación transcripcional
(2008)
Los principales objetivos de esta Tesis Doctoral son: Desarrollo de un nuevo método para el estudio de la distribución ... |
Patente. Invención
Soporte sólido para la unión y/o síntesis química en fase sólida y procedimiento de utilización
(Oficina Española de Patentes y Marcas (OEPM), 2007)
Soporte sólido para la unión y/o síntesis química en fase sólida y procedimiento de utilización. En la presente invención ... |
Patente. Invención
Procedimiento y dispositivo para la obtención de partículas de tamaño micro y nanométrico
(Oficina Española de Patentes y Marcas (OEPM), 2007)
Procedimiento y dispositivo para la obtención de partículas de tamaño micro y nanométrico. La presente invención está ... |
Tesis Doctoral
Elongación transcripcional en Saccharomyces Cerevisiae influencia en el control del ciclo celular y nuevas herramientas para su estudio "in vivo"
(2007)
La transcripción es el proceso mediante el cual la información genética, contenida en el DNA, es expresada en forma de ... |
| Artículo |
| Tesis Doctoral |
Artículo
Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation
(Elsevier, 2006)
Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates ... |
Artículo
A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region
(2006)
The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in ... |
Patente. Invención
Matrices de conductos capilares de utilidad quimica y biologica
(Oficina Española de Patentes y Marcas , 2003)
Matrices de conductos capilares de utilidad química y biológica.El objeto de esta invención es un procedimiento para la ... |
Artículo
Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae
(American Society for Microbiology, 2001)
Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome stability ... |
Artículo
The presence of glutamate dehydrogenase is a selective advantage for the cyanobacterium Synechocystis sp. strain PCC 6803 under nonexponential growth conditions
(American Society for Microbiology, 1999)
he unicellular cyanobacterium Synechocystis sp. strain PCC 6803 has two putative pathways for ammonium assimilation: the ... |
Artículo
The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
(Cold Spring Harbor Laboratory Press, 1997)
The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have ... |
Artículo
Nucleosome-mediated synergism between transcription factors on the mouse mammary tumor virus promoter
(National Academy of Sciences, 1997)
In unstimulated mammalian cells and in Saccharomyces cerevisiae, the mouse mammary tumor virus (MMTV) promoter is silent ... |
Artículo
Effect of Glucose Utilization on Nitrite Excretion by the Unicellular Cyanobacterium Synechocystis sp. Strain PCC 6803
(American Society for Microbiology, 1993)
Up to 1 mM nitrite was excreted by Synechocystis strain 6803 cells growing under mixotrophic or photoheterotrophic conditions. ... |
Tesis Doctoral
Glutamato deshidrogenasas en cianobacterias
(1992)
La finalidad del trabajo que aquí se presenta es contribuir al conocimiento de la función desarrollada por la actividad ... |