Artículo
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Autor/es | Medina, Daniel A.
Jordán Pla, Antonio Millán Zambrano, Gonzalo Chávez de Diego, Sebastián Pérez Ortín, José E. |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2014 |
Fecha de depósito | 2017-03-08 |
Publicado en |
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Resumen | The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has ... The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects. In a previous study, our group showed that deletion of all tested components of the yeast major decaysome, including XRN1, results in a decrease in the synthetic rate and an increase in half-life of most mRNAs in a compensatory manner. Furthermore, the same study showed that the all tested decaysome components are also nuclear proteins that bind to the 5′ region of a number of genes. In the present work, we show that disruption of Xrn1 activity preferentially affects both the synthesis and decay of a distinct subpopulation of mRNAs. The most affected mRNAs are the transcripts of the highly transcribed genes, mainly those encoding ribosome biogenesis and translation factors. Previously, we proposed that synthegradases play a key role in regulating both mRNA synthesis and degradation. Evidently, Xrn1 functions as a synthegradase, whose selectivity might help coordinating the expression of the protein synthetic machinery. We propose to name the most affected genes “Xrn1 synthegradon.” |
Identificador del proyecto | BFU2010-21975-C03-01
BFU2010-21975-C03-02 P07-CVI-02623 P08-CVI-03508 |
Cita | Medina, D.A., Jordán Pla, A., Millán Zambrano, G., Chávez de Diego, S. y Pérez Ortín, .E. (2014). Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast. Frontiers in genetics, 5 (1), 1-10. |
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