dc.creator | Medrano Padial, Concepción | es |
dc.creator | Puerto Rodríguez, María | es |
dc.creator | Moreno Onorato, Francisco Javier | es |
dc.creator | Richard, Tristan | es |
dc.creator | Cantos Villar, Emma | es |
dc.creator | Pichardo Sánchez, Silvia | es |
dc.date.accessioned | 2019-11-07T17:45:35Z | |
dc.date.available | 2019-11-07T17:45:35Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Medrano Padial, C., Puerto Rodríguez, M., Moreno Onorato, F.J., Richard, T., Cantos Villar, E. y Pichardo Sánchez, S. (2019). In Vitro Toxicity Assessment of Stilbene Extract for Its Potential Use as Antioxidant in the Wine Industry. Antioxidants, 8 (10 art. 467), 1-16. | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/90065 | |
dc.description.abstract | The reduction of sulfur dioxide in wine is a consumer’s demand, considering the allergic effects that may occur in people who are sensitive to it. Stilbenes are candidates of great interest for this purpose because of their antioxidant/antimicrobial activities and health properties, and also because they are naturally found in the grapevine. In the present study, the in vitro toxicity of an extract from grapevine shoots (with a stilbene richness of 45.4%) was assessed in two human cell lines. Significant damage was observed from 30 μg/mL after 24 h, and 40 µg/mL after 48 h of exposure. Similarly, the ultrastructural study revealed a significant impairment of cell growing. The extract was able to protect cells against an induced oxidative stress at all concentrations studied. In view of the promising results, a more exhaustive toxicological assessment of the extract is needed to confirm the safety of its further use as additive in wine. | es |
dc.description.sponsorship | España,Ministerio de Economía, Industria y Competitividad and INIA for the financial support for this project (RTA2015-00005-C02-02) | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antioxidants, 8 (10 art. 467), 1-16. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Caco-2 | es |
dc.subject | Hep-G2 | es |
dc.subject | antioxidant | es |
dc.subject | cytotoxicity | es |
dc.subject | stilbene | es |
dc.subject | wine | es |
dc.title | In Vitro Toxicity Assessment of Stilbene Extract for Its Potential Use as Antioxidant in the Wine Industry | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.relation.projectID | RTA2015-00005-C02-02 | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox8100467 | es |
dc.identifier.doi | 10.3390/antiox8100467 | es |
idus.format.extent | 16 p. | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 10 art. 467 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 16 | es |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Farmacia | |