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Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake

 

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Opened Access Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake
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Author: Espada, Caroline R.
Magalhães,Rubens M.
Cruz, Mario C.
Hornillos Gómez-Recuero, Valentín
Department: Universidad de Sevilla. Departamento de Química Orgánica
Date: 2019
Published in: International Journal for Parasitology: Drugs and Drug Resistance, 18, 1-9.
Document type: Article
Abstract: In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly related to drug toxicity and reduced efficacy in some regions. Miltefosine (MF), the only ora...
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Cite: Espada, C.R., Magalhães, u.M., Cruz, M.C. y Hornillos Gómez-Recuero, V. (2019). Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake. International Journal for Parasitology: Drugs and Drug Resistance, 18, 1-9.
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Format: PDF

URI: https://hdl.handle.net/11441/85403

DOI: 10.1016/j.ijpddr.2019.02.005

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