Opened Access Epigenetic features of human telomeres

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Autor: Cubiles de la Vega, María Dolores
Barroso Ceballos, Sonia Inés
Vaquero Sedas, María Isabel
Enguix Gonzalez, Alicia
Aguilera López, Andrés
Vega Palas, Miguel Ángel
Departamento: Universidad de Sevilla. Departamento de Estadística e Investigación Operativa
Centro Andaluz de Investigaciones en Biología Molecular y Medina Regenerativa (CABIMER)
Instituto de Bioquímica Vegetal y Fotosíntesis IBVF – CIC Cartuja
Fecha: 2018
Publicado en: Nucleic Acids Research, 46 (5), 2347-2355.
Tipo de documento: Artículo
Resumen: Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. This controversy might have been influenced by the confounding effect of subtelomeric regions and interstitial telomeric sequences (ITSs) on telomeric chromatin structure analyses. In addition, different human cell lines might carry diverse epigenetic marks at telomeres. We have developed a reliable procedure to study the chromatin structure of human telomeres independently of subtelomeres and ITSs. This procedure is based on the statistical analysis of multiple ChIP-seq experiments. We have found that human telomeres are not enriched in the heterochromatic H3K9me3 mark in most of the common laboratory cell lines, including embryonic stem cells. Instead, they are labeled with H4K20me1 and H3K27ac, which might be established by p300. These results together with previously published data argue that subtelomeric heterochromatin might control human telomere function...
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Cita: Cubiles de la Vega, M.D., Barroso Ceballos, S.I., Vaquero Sedas, M.I., Enguix Gonzalez, A., Aguilera López, A. y Vega Palas, M.Á. (2018). Epigenetic features of human telomeres. Nucleic Acids Research, 46 (5), 2347-2355.
Tamaño: 1.476Mb
Formato: PDF

URI: https://hdl.handle.net/11441/79226

DOI: 10.1093/nar/gky006

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