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Evidence of the Red-Queen Hypothesis from Accelerated Rates of Evolution of Genes Involved in Biotic Interactions in Pneumocystis


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dc.creator Delaye, Luis es
dc.creator Ruiz-Ruiz, Susana es
dc.creator Calderon, Enrique es
dc.creator Tarazona, Sonia es
dc.creator Conesa, Ana es
dc.creator Moya, Andrés es 2018-10-08T11:28:23Z 2018-10-08T11:28:23Z 2018-06-11
dc.identifier.citation Delaye, L., Ruiz-Ruiz, S., Calderon, E., Tarazona, S., Conesa, A. y Moya, A. (2018). Evidence of the Red-Queen Hypothesis from Accelerated Rates of Evolution of Genes Involved in Biotic Interactions in Pneumocystis. Genome Biology and Evolution, 10 (6), 1596-1606.
dc.identifier.issn 1759-6653 es
dc.description.abstract Pneumocystis species are ascomycete fungi adapted to live inside the lungs of mammals. These ascomycetes show extensive stenoxenism, meaning that each species of Pneumocystis infects a single species of host. Here, we study the effect exerted by natural selection on gene evolution in the genomes of three Pneumocystis species. We show that genes involved in host interaction evolve under positive selection. In the first place, we found strong evidence of episodic diversifying selection in Major surface glycoproteins (Msg). These proteins are located on the surface of Pneumocystis and are used for host attachment and probably for immune system evasion. Consistent with their function as antigens, most sites under diversifying selection in Msg code for residues with large relative surface accessibility areas. We also found evidence of positive selection in part of the cell machinery used to export Msg to the cell surface. Specifically, we found that genes participating in glycosylphosphatidylinositol (GPI) biosynthesis show an increased rate of nonsynonymous substitutions (dN) versus synonymous substitutions (dS). GPI is a molecule synthesized in the endoplasmic reticulum that is used to anchor proteins to membranes. We interpret the aforementioned findings as evidence of selective pressure exerted by the host immune system on Pneumocystis species, shaping the evolution of Msg and several proteins involved in GPI biosynthesis. We suggest that genome evolution in Pneumocystis is well described by the Red-Queen hypothesis whereby genes relevant for biotic interactions show accelerated rates of evolution. es
dc.description.sponsorship European Community 612583-DEANN es
dc.description.sponsorship CONACYT 454938 es
dc.description.sponsorship Spanish Ministry of Science and Competitivity SAF 2012-31187 SAF2013-49788-EXP SAF2015-65878-R es
dc.description.sponsorship Carlos III Institute of Health PIE14/00045 AC 15/00022 AC15/00042 es
dc.description.sponsorship Generalitat Valenciana PrometeoII/2014/065 es
dc.description.sponsorship FEDER PrometeoII/2014/065 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Oxford University Press es
dc.relation.ispartof Genome Biology and Evolution, 10 (6), 1596-1606.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.subject Stenoxenism es
dc.subject Majors surface glycoproteins es
dc.subject Glycosylphosphatidylinositol es
dc.subject Natural selection es
dc.title Evidence of the Red-Queen Hypothesis from Accelerated Rates of Evolution of Genes Involved in Biotic Interactions in Pneumocystis es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Instituto de Biomedicina de Sevilla (IBIS) es
dc.relation.projectID 612583-DEANN es
dc.relation.projectID 454938 es
dc.relation.projectID SAF 2012-31187 es
dc.relation.projectID SAF2013-49788-EXP es
dc.relation.projectID SAF2015-65878-R es
dc.relation.projectID PIE14/00045 es
dc.relation.projectID AC 15/00022 es
dc.relation.projectID AC15/00042 es
dc.relation.projectID PrometeoII/2014/065 es
dc.relation.publisherversion es
dc.identifier.doi 10.1093/gbe/evy116 es
idus.format.extent 11 p. es
dc.journaltitle Genome Biology and Evolution es
dc.publication.volumen 10 es
dc.publication.issue 6 es
dc.publication.initialPage 1596 es
dc.publication.endPage 1606 es
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