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dc.creatorVaran, Gamzees
dc.creatorOrtiz Mellet, Carmenes
dc.creatorBenito, Juan M.es
dc.creatorBilensoy, Eremes
dc.date.accessioned2018-05-17T09:31:47Z
dc.date.available2018-05-17T09:31:47Z
dc.date.issued2017
dc.identifier.citationVaran, G., Ortiz Mellet, C., Benito, J.M. y Bilensoy, . (2017). Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery. Beilstein Journal of Nanotechnology, 8, 1457-1468.
dc.identifier.issn2190-4286es
dc.identifier.urihttps://hdl.handle.net/11441/74732
dc.description.abstractBackground: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphilic cyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre-formulation studies were used as a basis for selecting the suitable organic solvent and surfactant concentration for the novel polycationic cyclodextrin nanoparticles. The nanoparticles were then extensively characterized with particle size distribution, polydispersity index, zeta potential, drug loading capacity, in vitro release profiles and cytotoxicity studies. Results: Paclitaxel-loaded cyclodextrin nanoparticles were obtained in the diameter range of 80−125 nm (depending on the nature of the cyclodextrin derivative) where the smallest diameter nanoparticles were obtained with polycationic (PC) βCDC6. A strong positive charge also helped to increase the loading capacity of the nanoparticles with paclitaxel up to 60%. Interestingly, cyclodextrin nanoparticles were able to stabilize paclitaxel in aqueous solution for 30 days. All blank cyclodextrin nanoparticles were demonstrated to be non-cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO. Conclusion: According to the results of this study, both amphiphilic cyclodextrin derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphilic cyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for self-assembled nanometer-sized drug carrier systems for safe and efficient chemotherapy.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.relation.ispartofBeilstein Journal of Nanotechnology, 8, 1457-1468.
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectamphiphilic cyclodextrines
dc.subjectanticanceres
dc.subjectnanoparticlees
dc.subjectpaclitaxeles
dc.subjectpolycationices
dc.titleDevelopment of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug deliveryes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.publisherversionhttp://dx.doi.org/10.3762/bjnano.8.145es
dc.identifier.doi10.3762/bjnano.8.145es
idus.format.extent11 p.es
dc.journaltitleBeilstein Journal of Nanotechnologyes
dc.publication.volumen8es
dc.publication.initialPage1457es
dc.publication.endPage1468es

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Except where otherwise noted, this item's license is described as: Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América