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The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

Opened Access The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

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Autor: García Moreno, M. Isabel
Ortega Caballero, Fernando
Rísquez Cuadro, Rocio
García Fernández, José Manuel
Ortiz Mellet, Carmen
Fecha: 2017
Publicado en: Chemistry a European Journal, 23 (26), 6295-6304.
Tipo de documento: Artículo
Resumen: The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its putative sugar ligand (glycotope) has proven too simplistic. On the one hand, binding of a glycotope in a dense glycocalix-like construct to a lectin partner has been shown to be sensitive to the presence of a third sugar entity (heterocluster effect). On the other hand, several carbohydrate processing enzymes (glycosidases and glycosyltransferases) have been found to be also responsive to multivalent presentations of binding partners (multivalent enzyme inhibition), a phenomenon first discovered for iminosugar-type inhibitory species (inhitopes) and recently demonstrated for multivalent carbohydrate constructs. By assessing a series of homo- and heteroclusters combining α-d-glucopyranosyl-related glycotopes and inhitopes, it was shown that multivalency and heteromultivalency govern both kinds of events, allowing for activation, deactivation or enhancement of specific r...
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Cita: García-Moreno, M.I., Ortega-Caballero, F., Rísquez-Cuadro, R., García-Fernández, J.M. y Ortiz Mellet, C. (2017). The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study. Chemistry a European Journal, 23 (26), 6295-6304.
Tamaño: 608.5Kb
Formato: PDF

URI: https://hdl.handle.net/11441/74709

DOI: 10.1002/chem.201700470

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