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hSiah2 is a new vav binding protein which inhibits Vav-mediated signaling pathways

Opened Access hSiah2 is a new vav binding protein which inhibits Vav-mediated signaling pathways

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Autor: Germani, Antonia
Romero Portillo, Francisco
Houlard, Martin
Camonis, Jacques H.
Gisselbrecht, Sylvie
Fischer, Siegmund
Varin-Blank, Nadine
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 1999
Publicado en: Molecular and Cellular Biology, 19 (5), 3798-3807.
Tipo de documento: Artículo
Resumen: The hematopoietic proto-oncogene vav has been characterized as a Rac1- GDP/GTP exchanger protein which regulates cytoskeletal reorganization as well as signaling pathways leading to the activation of stress-activated protein kinases (SAPK/JNKs). Furthermore, vav overexpression enhances basal and T- cell receptor (TCR)-mediated stimulation of the nuclear factor of activated T cells (NFAT). We report here the interaction between Vav and hSiah2, a mammalian homolog of Drosophila Seven in absentia (Sina) that has been implicated in R7 photoreceptor cell formation during Drosophila eye development via the proteasome degradation pathway. Vav and hSiah2 interact in vitro and in vivo and colocalize in the cytoplasm of hematopoietic cells. The Src homology domain of Vav and the C-terminal region of hSiah2 are required for this interaction. We provide evidence for a negative regulation by hSiah2 of Vav-induced basal and TCR-mediated NFAT-dependent transcription. Overexpression of hSiah2 also in...
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Cita: Germani, A., Romero Portillo, F., Houlard, M., Camonis, J.H., Gisselbrecht, S., Fischer, S. y Varin-Blank, N. (1999). hSiah2 is a new vav binding protein which inhibits Vav-mediated signaling pathways. Molecular and Cellular Biology, 19 (5), 3798-3807.
Tamaño: 1.798Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70837

DOI: 10.1128/MCB.19.5.3798

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