Perfil del autor: Romero Portillo, Francisco
Datos institucionales
| Nombre | Romero Portillo, Francisco |
| Departamento | Microbiología |
| Área de conocimiento | Microbiología |
| Categoría profesional | Catedrático de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
25
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Nº visitas
3537
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Nº descargas
3596
| Publicaciones |
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Tesis Doctoral
 Estudio de la ubicuitilación del complejo MRN mediada por SCF(bTrCP/FBXW7): implicaciones biológicas
(2023)
El cisplatino, como otros fármacos basados en platino, se encuentra entre los compuestos más usados en las quimioterapias ... |
Artículo
 Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway
(Springer Nature, 2023)
Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment ... |
Artículo
SNRPD2 Is a Novel Substrate for the Ubiquitin Ligase Activity of the Salmonella Type III Secretion Effector SlrP
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
SlrP is a protein with E3 ubiquitin ligase activity that is translocated by Salmonella enterica serovar Typhimurium into ... |
Artículo
Wnt/β-Catenin Signaling Contributes to Paclitaxel Resistance in Bladder Cancer Cells with Cancer Stem Cell-Like Properties
(MDPI, 2021)
The Wnt/β-catenin pathway plays an important role in tumor progression and chemother apy resistance and seems to be essential ... |
Artículo
Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1
(MDPI, 2020)
Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to ... |
Artículo
p53 and FBXW7: Sometimes Two Guardians Are Worse than One
(MDPI, 2020)
Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute ... |
Artículo
EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells
(Springer Nature, 2020)
Epithelial–mesenchymal transition (EMT) has recently been associated with tumor progression, metastasis, and chemotherapy ... |
Tesis Doctoral
Importancia de la desregulación de la degradación de proteínas del ciclo celular en el cáncer
(2019)
La viabilidad de las células depende del buen funcionamiento de un conjunto de mecanismos moleculares que controlan los ... |
Artículo
Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
(MDPI, 2018)
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and ... |
Artículo
Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer
(Nature Publishing Group, 2017)
Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic ... |
Artículo
Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer
(Impact Journals, 2016)
FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins ... |
Tesis Doctoral
Búsqueda de nuevos sustratos de SCF-bTrCP implicados en tumorigénesis
(2015)
Esta Tesis se centra en la búsqueda de nuevos sustratos de SCFbTrCP, una ligasa de ubicuitina esencial en la regulación ... |
Artículo
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism
(Nature, 2015)
Targeting the ubiquitin proteasome pathway has emerged as a rational approach in the treatment of human cancers. Autophagy ... |
Artículo
SCFFBXW7α modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability
(Impact Journals LLC, 2014)
The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response ... |
Artículo
βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy
(Impact Journals, 2014)
n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the ... |
Tesis Doctoral
Análisis Funcional de la Fosforilación de Securina
(2011)
El objetivo de esta Tesis se engloba dentro de un estudio más amplio sobre el análisis funcional de la fosforilación de ... |
Artículo
Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.
(The American Society for Biochemistry and Molecular Biology, 2011)
PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during ... |
Artículo
UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase
(Company of Biologists, 2008)
Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid ... |
Tesis Doctoral
Regulación de la estabilidad de la oncoproteína PTTG1/hSecurina
(2007)
El objetico de esta Tesis es el estudio de la relación de la estabilidad de la oncoproteína PTTG1/Sec. Para ello nos ... |
Artículo
Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase
(2006)
Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. ... |
Artículo
Securin Is a Target of the UV Response Pathway in Mammalian Cells
(2004)
All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing ... |
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Artículo
hSiah2 is a new vav binding protein which inhibits Vav-mediated signaling pathways
(1999)
The hematopoietic proto-oncogene vav has been characterized as a Rac1- GDP/GTP exchanger protein which regulates cytoskeletal ... |
Artículo
Grb2 and Its Apoptotic Isoform Grb3-3 Associate with Heterogeneous Nuclear Ribonucleoprotein C, and These Interactions Are Modulated by Poly(U) RNA
(Elsevier, 1998)
Grb2 is an adaptor molecule comprising one Src homology (SH) 2 and two SH3 domains. This protein has a natural isoform ... |
Tesis Doctoral
Estudio genético de la nodulación de "Rhizobium fredii"
(1993)
En esta tesis se han estudiado diversos aspectos de la nodulación de las estirpes de Rhizobium fredii. Esta especie está ... |