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Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies

Opened Access Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies

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Autor: Jiménez Blanco, José Luis
Ortiz Mellet, Carmen
García Fernández, José Manuel
Departamento: Universidad de Sevilla. Departamento de Química orgánica
Fecha: 2013
Publicado en: Chemical Society Reviews, 42, 4518-4531.
Tipo de documento: Artículo
Resumen: Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported multivalent carbohydrate prototypes barely reflect the inherent heterogeneity of biological systems, therefore underestimating the potential contribution of synergistic or antagonistic effects to molecular recognition events. To address this question, the design of novel molecular and supramolecular entities displaying different saccharide motifs in a controlled manner is of critical importance. In this review we highlight the current efforts made to synthesize heteromultivalent glycosystems on different platforms (peptides, dendrimers, polymers, oligonucleotides, calixarenes, cyclodextrins, microarrays, vesicles) and to evaluate the influence of heterogeneity in carbohydrate-protein (lectin, antibody) recognition phenomena. Although the number of publications on this topic is limited as compared to the huge volume of reports on homomultivalent sugar displays, the curren...
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Cita: Jiménez Blanco, J.L., Ortiz Mellet, C. y García Fernández, J.M. (2013). Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies. Chemical Society Reviews, 42, 4518-4531.
Tamaño: 4.927Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70415

DOI: 10.1039/c2cs35219b

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