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Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones

 

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Opened Access Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones
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Author: Marqués López, Eugenia
Díez Martín, Elena
Martín Zamora, Eloísa
Álvarez González, Eleuterio
Fernández Fernández, Rosario Fátima
Lassaletta Simón, José María
Department: Universidad de Sevilla. Departamento de Química orgánica
Date: 2012
Published in: Synlett, 23 (6), 885-888.
Document type: Article
Abstract: Reaction of N-acylhydrazones with benzyloxyacetyl chloride in the presence of i-Pr 2EtN affords new 1,3,4-oxadiazolines in excellent yields (72-95%), under mild reaction conditions and in short reaction times. The structures of the products were confirmed by single-crystal X-ray diffractometry. A plausible reaction mechanism is proposed
Cite: Marqués López, E., Díez Martín, E., Martín Zamora, E., Álvarez, E., Fernández Fernández, R. y Lassaletta Simón, J.M. (2012). Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones. Synlett, 23 (6), 885-888.
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URI: https://hdl.handle.net/11441/70183

DOI: 10.1055/s-0031-1290609

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