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Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach

 

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Opened Access Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach
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Author: Macchione, Giuseppe
Paz Carrera, Jose Luis de
Nieto Mesa, Pedro Manuel
Date: 2014
Published in: Carbohydrate Research, 395, 17-25.
Document type: Article
Abstract: The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared.
Cite: Macchione, G., Paz Carrera, J.L.d. y Nieto Mesa, P.M. (2014). Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach. Carbohydrate Research, 395, 17-25.
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URI: https://hdl.handle.net/11441/69625

DOI: 10.1016/j.carres.2014.05.007

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