Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach

Macchione, Giuseppe; Paz Carrera, Jose Luis de; Nieto Mesa, Pedro Manuel

doi:10.1016/j.carres.2014.05.007

Artículo

dc.creator	Macchione, Giuseppe	es
dc.creator	Paz Carrera, Jose Luis de	es
dc.creator	Nieto Mesa, Pedro Manuel	es
dc.date.accessioned	2018-01-26T15:16:40Z
dc.date.available	2018-01-26T15:16:40Z
dc.date.issued	2014
dc.identifier.citation	Macchione, G., Paz Carrera, J.L.d. y Nieto Mesa, P.M. (2014). Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach. Carbohydrate Research, 395, 17-25.
dc.identifier.issn	0008-6215 (impreso)	es
dc.identifier.issn	1873-426X (electrónico)	es
dc.identifier.uri	https://hdl.handle.net/11441/69625
dc.description.abstract	The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the puriﬁcation of synthetic intermediates, a ﬂuorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared.	es
dc.description.sponsorship	Ministerio de Economía y Competitividad CTQ2009- 07168, CTQ2012-32605	es
dc.format	application/pdf	es
dc.language.iso	eng	es
dc.publisher	Elsevier	es
dc.relation.ispartof	Carbohydrate Research, 395, 17-25.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Hyaluronic acid	es
dc.subject	Glycosylation	es
dc.subject	Fluorous tag	es
dc.subject	Oligosaccharide synthesis	es
dc.subject	Glucuronic acid	es
dc.subject	Carbohydrates	es
dc.title	Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach	es
dc.type	info:eu-repo/semantics/article	es
dc.type.version	info:eu-repo/semantics/submittedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.relation.projectID	CTQ2009- 07168	es
dc.relation.projectID	CTQ2012-32605	es
dc.relation.publisherversion	http://dx.doi.org/10.1016/j.carres.2014.05.007	es
dc.identifier.doi	10.1016/j.carres.2014.05.007	es
idus.format.extent	29 p.	es
dc.journaltitle	Carbohydrate Research	es
dc.publication.volumen	395	es
dc.publication.initialPage	17	es
dc.publication.endPage	25	es
dc.contributor.funder	Ministerio de Economía y Competitividad (MINECO). España

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