Article
Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach
Author/s | Macchione, Giuseppe
Paz Carrera, Jose Luis de Nieto Mesa, Pedro Manuel |
Publication Date | 2014 |
Deposit Date | 2018-01-26 |
Published in |
|
Abstract | The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably ... The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared. |
Funding agencies | Ministerio de Economía y Competitividad (MINECO). España |
Project ID. | CTQ2009- 07168
CTQ2012-32605 |
Citation | Macchione, G., Paz Carrera, J.L.d. y Nieto Mesa, P.M. (2014). Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach. Carbohydrate Research, 395, 17-25. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Synthesis of hyaluronic acid ... | 295.1Kb | [PDF] | View/ | |