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Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar ty phimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy

Opened Access Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar ty phimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy

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Autor: Núñez Hernández, Cristina
Tierrez, Alberto
D. Ortega, Álvaro
Pucciarelli, María Graciela
Godoy, Marta
Eisman, Blanca
Casadesús Pursals, Josep
García del Portillo, Francisco
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2013-01
Publicado en: Infection and Immunity, 81 (1), 154-165.
Tipo de documento: Artículo
Resumen: Genome-wide expression analyses have provided clues on how Salmonella proliferates inside cultured macrophages and epithelial cells. However, in vivo studies show that Salmonella does not replicate massively within host cells, leaving the underlyingmechanisms of such growth control largely undefined. In vitro infection models based on fibroblasts or dendritic cells reveal limited proliferation of the pathogen, but it is presently unknown whether these phenomena reflect events occurring in vivo. Fibroblasts are distinctive, since they represent a nonphagocytic cell type in which S. enterica serovar Typhimurium actively attenuates intracellular growth. Here, we show in the mouse model that S. Typhimurium restrains intracellular growth within nonphagocytic cells positioned in the intestinal lamina propria. This response requires a functional PhoP-PhoQ system and is reproduced inprimary fibroblasts isolated from the mouse intestine. The fibroblast infection model was exploited to generate...
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Cita: Núñez Hernández, C., Tierrez, A., D. Ortega, Á., Pucciarelli, M.G., Godoy, M., Eisman, B.,...,García del Portillo, F. (2013). Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar ty phimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy. Infection and Immunity, 81 (1), 154-165.
Tamaño: 2.126Mb
Formato: PDF

URI: http://hdl.handle.net/11441/62639

DOI: 10.1128/IAI.01080-12

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