dc.creator | Miguel Rodríguez, Manuel de | es |
dc.creator | Fernández-Santos, José María | es |
dc.creator | Utrilla Alcolea, José Carmelo | es |
dc.creator | Carrillo Vico, Antonio | es |
dc.creator | Borrero, J. | es |
dc.creator | Conde Amiano, Esperanza | es |
dc.creator | Guerrero Montávez, Juan Miguel | es |
dc.creator | Martín Lacave, Inés María | es |
dc.date.accessioned | 2017-05-16T07:52:51Z | |
dc.date.available | 2017-05-16T07:52:51Z | |
dc.date.issued | 2005-07-01 | |
dc.identifier.citation | Miguel Rodríguez, M.d., Fernández-Santos, J.M., Utrilla, J.C., Carrillo Vico, A., Borrero, J., Conde Amiano, E.,..., Martín Lacave, I.M.(2005). Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?. Histology and Histopathology, 20 (3), 713-718. | |
dc.identifier.issn | 02133911 | es |
dc.identifier.uri | http://hdl.handle.net/11441/59852 | |
dc.description.abstract | Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Immunoreactivity for TRH and TRH-like peptides has been found in some tissues outside the nervous system, including thyroid. It has been demonstrated that thyroid C-cells express authentic TRH, affecting thyroid hormone secretion by follicular cells. Therefore, C-cells could have a paracrine role in thyroid homeostasis. If this hypothesis is true, follicular cells should express TRH receptors (TRH-Rs) for the paracrine modulation carried out by C-cells. In order to elucidate whether or not C-cell TRH production could act over follicular cells modulating thyroid function, we studied TRH-Rs expression in PC C13 follicular cells from rat thyroid, by means of immunofluorescence technique and RT-PCR analysis. We also investigated the possibility that C-cells present TRH-Rs for the autocrine control of its own TRH production. Our results showed consistent expression for both receptors, TRH-R1 and TRH-R2, in 6-23 C-cells, and only for TRH-R2 in PC C13 follicular cells. Our data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation.ispartof | Histology and Histopathology, 20 (3), 713-718. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Rat thyroid | es |
dc.subject | Follicular cells | es |
dc.title | Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells? | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
idus.format.extent | 6 | es |
dc.journaltitle | Histology and Histopathology | es |
dc.publication.volumen | 20 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 713 | es |
dc.publication.endPage | 718 | es |