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Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model

 

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Opened Access Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
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Author: Kavanagh, Edel T.
Burguillos García, Miguel Ángel
Carrillo Jiménez, Alejandro
Oliva Martín, María José
Santiago Pavón, Martiniano
Rodhe, Johanna
Joseph, Bertrand
Venero Recio, José Luis
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2015
Published in: Aging, 7 (9), 673-689.
Document type: Article
Abstract: Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and unexpected role for caspase...
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Cite: Kavanagh, E., Burguillos García, M.Á., Carrillo Jiménez, A., Oliva Martín, M.J., Santiago Pavón, M., Rodhe, J.,...,Venero Recio, J.L. (2015). Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model. Aging, 7 (9), 673-689.
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URI: http://hdl.handle.net/11441/54639

DOI: 10.18632/aging.100805

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