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Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives

Opened Access Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives

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Autor: Sanz-Herrera, Jose Antonio
Reina-Romo, Esther
Departamento: Universidad de Sevilla. Departamento de Ingeniería Mecánica y de Fabricación
Fecha: 2011-11-21
Publicado en: International Journal of Molecular Sciences, 12 (11), 8217-8244.
Tipo de documento: Artículo
Resumen: Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engineering product. Cell-biomaterial interaction is referred to here as the phenomenon involved in adherent cells attachment to the biomaterial surface, and their related cell functions such as growth, differentiation, migration or apoptosis. This process is inherently complex in nature involving many physico-chemical events which take place at different scales ranging from molecular to cell body (organelle) levels. Moreover, it has been demonstrated that the mechanical environment at the cell-biomaterial location may play an important role in the subsequent cell function, which remains to be elucidated. In this paper, the state-of-the-art research in the physics a...
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Cita: Sanz-Herrera, J.A. y Reina-Romo, E. (2011). Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives. International Journal of Molecular Sciences, 12 (11), 8217-8244.
Tamaño: 4.036Mb
Formato: PDF

URI: http://hdl.handle.net/11441/53656

DOI: 10.3390/ijms12118217

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