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Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death

Opened Access Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
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Autor: Carriba, Paulina
Jiménez, Sebastián
Navarro, Victoria
Moreno González, Inés
Barneda Zahonero, Bruna
Vitorica Ferrández, Francisco Javier
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 2015
Publicado en: Cell Death and Disease, 6 (2), 1-13.
Tipo de documento: Artículo
Resumen: The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine that has a dual function in neuronal cells. On one hand, TNFα can activate neuronal apoptosis, and on the other hand, it can protect these cells against amyloid-β (Aβ) toxicity. Given the dual behavior of this molecule, there is some controversy regarding its contribution to the pathogenesis of AD. Here we examined the relevance of the long form of Fas apoptotic inhibitory molecule (FAIM) protein, FAIM-L, in regulating the dual function of TNFα. We detected that FAIM-L was reduced in the hippocampi of patients with AD. We also observed that the entorhinal and hippocampal cortex of a mouse model of AD (PS1M146LxAPP751sl) showed a reduction in this protein before the onset of neurodegeneration. Notably, cultured neurons treated with the cortical soluble fractions of these animals showed a decrease in endogenous FAIM-L, an effect that is mimicked by the treatment wit...
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Cita: Carriba, P., Jiménez, S., Navarro, V., Moreno González, I., Barneda Zahonero, B. y Vitorica Ferrández, F.J. (2015). Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. Cell Death and Disease, 6 (2), 1-13.
Tamaño: 2.431Mb
Formato: PDF

URI: http://hdl.handle.net/11441/50581

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