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Prospective Multicenter Study of the Impact of Carbapenem Resistance on Mortality in Pseudomonas aeruginosa Bloodstream Infections

Opened Access Prospective Multicenter Study of the Impact of Carbapenem Resistance on Mortality in Pseudomonas aeruginosa Bloodstream Infections

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Autor: Peña, Carmen
Suárez, Cristina
Gozalo, Mónica
Murillas, Javier
Almirante, Benito
Pomar, Virginia
Aguilar, Manuela
Granados, Ana
Calbo, Esther
Rodríguez-Baño, Jesús
Rodríguez, Fernando
Tubau, Fe
Martínez-Martínez, Luis
Oliver, Antonio
Departamento: Universidad de Sevilla. Departamento de Medicina
Fecha: 2012
Publicado en: Antimicrobial Agents and Chemotherapy, 56(3), 1265–1272
Tipo de documento: Artículo
Resumen: The impact of antimicrobial resistance on clinical outcomes is the subject of ongoing investigations, although uncertainty remains about its contribution to mortality. We investigated the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa bacteremia in a prospective multicenter (10 teaching hospitals) observational study of patients with monomicrobial bacteremia followed up for 30 days after the onset of bacteremia. The adjusted influence of carbapenem resistance on mortality was studied by using Cox regression analysis. Of 632 episodes, 487 (77%) were caused by carbapenem-susceptible P. aeruginosa (CSPA) isolates, and 145 (23%) were caused by carbapenem-resistant P. aeruginosa (CRPA) isolates. The median incidence density of nosocomial CRPA bacteremia was 2.3 episodes per 100,000 patient-days (95% confidence interval [CI], 1.9 to 2.8). The regression demonstrated a time-dependent effect of carbapenem resistance on mortality as well as a significant interaction wi...
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Tamaño: 401.4Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41288

DOI: http://dx.doi.org/10.1128/AAC.05991-11

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