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Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons

Opened Access Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons

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Autor: Davis López de Carrizosa, María América
Morado Díaz, Camilo José
Tena, Juan J.
Benítez Temiño, Beatriz
Pecero, María L.
Morcuende Fernández, Sara R.
Pastor Loro, Ángel Manuel
Rodríguez de la Cruz, Rosa María
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2009
Publicado en: Journal of Neuroscience, 29(2),575-587
Tipo de documento: Artículo
Resumen: Neurotrophins, as target-derived factors, are essential for neuronal survival during development, but during adulthood, their scope of actions widens to become also mediators of synaptic and morphological plasticity. Target disconnection by axotomy produces an initial synaptic stripping ensued by synaptic rearrangement upon target reinnervation. Using abducens motoneurons of the oculomotor system as a model for axotomy, we report that trophic support by brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or a mixture of both, delivered to the stump of severed axons, results in either the prevention of synaptic stripping when administered immediately after lesion or in a promotion of reinnervation of afferents to abducens motoneurons once synaptic stripping had occurred, in concert with the recovery of synaptic potentials evoked from the vestibular nerve. Synaptotrophic effects, however, were larger when both neurotrophins were applied together. The axotomy-induced reductio...
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Tamaño: 8.419Mb
Formato: PDF

URI: http://hdl.handle.net/11441/40712

DOI: http://dx.doi.org/10.1523/JNEUROSCI.5312-08.2009

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