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Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa

Opened Access Alteration of light-dependent gene regulation by the absence of the RCO-1/RCM-1 repressor complex in the fungus Neurospora crassa

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Autor: Ruger Herreros, Carmen
Gil Sánchez, María del Mar
Sancar, Gencer
Brunner, Michael
Corrochano Peláez, Luis María
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2014
Publicado en: PLoS One, 9,  e95069
Tipo de documento: Artículo
Resumen: The activation of transcription by light in the fungus Neurospora crassa requires the White Collar Complex (WCC), a photoreceptor and transcription factor complex. After light reception two WCCs interact and bind the promoters of light- regulated genes to activate transcription. This process is regulated by VVD, a small photoreceptor that disrupts the interaction between WCCs and leads to a reduction in transcription after long exposures to light. The N. crassa RCO-1/RCM-1 repressor complex is the homolog of the Tup1-Ssn6 repressor complex in yeast, and its absence modifies photoadaptation. We show that the absence of the RCO-1/RCM-1 repressor complex leads to several alterations in transcription that are gene-specific: an increase in the accumulation of mRNAs in the dark, a repression of transcription, and a derepression of transcription after long exposures to light. The absence of the RCO-1/RCM-1 repressor complex leads to lower VVD levels that are available for the...
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Tamaño: 1.239Mb
Formato: PDF

URI: http://hdl.handle.net/11441/40566

DOI: http://dx.doi.org/10.1371/journal.pone.0095069

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