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New insights into the role of the immune microenvironment in breast carcinoma

Opened Access New insights into the role of the immune microenvironment in breast carcinoma
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Autor: Nieto García, María Adoración
Sánchez Margalet, Víctor
Alba Conejo, Emilio
Ruiz Borrego, Manuel
Cruz Merino, Luis de la
Codes Manuel de Villena, Manuel
Henao Carrasco, Fernando Manuel
Vallejo Benítez, Ana
Barco Sánchez, Antonio
Nogales Fernández, Esteban
Brugal Molina, Javier
Martínez Peinado, Antonio
Grueso López, Ana
Casares Lagar, Noelia
Ibáñez Martínez, José
Departamento: Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública
Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Universidad de Sevilla. Departamento de Medicina
Fecha: 2013
Publicado en: Clinical and Developmental Immunology (p.1-11)
Tipo de documento: Artículo
Resumen: Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) andmyeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice a...
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Tamaño: 1.350Mb
Formato: PDF

URI: http://hdl.handle.net/11441/18259

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