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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

 

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Opened Access Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
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Author: Gutiérrez Pérez, Antonia
Vitorica Ferrández, Francisco Javier
Dávila Cansino, José Carlos
Vizuete Chacón, María Luisa
Carmona Cuenca, Irene
Jiménez Muñoz, Sebastián
Trujillo Estrada, Laura Isabel
Sánchez Varo, Raquel María
Torres Canalejo, Manuel
Sánchez Mejías, Elisabeth
Navarro Garrido, Victoria
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2012
Published in: Molecular Neurodegeneration, 7 (59), 1-15.
Document type: Article
Abstract: Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies could reflect the disruptio...
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URI: http://hdl.handle.net/11441/18243

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