Repositorio de producción científica de la Universidad de Sevilla

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Opened Access Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Estadísticas
Icon
Exportar a
Autor: Gutiérrez Pérez, Antonia
Vitorica Ferrández, Francisco Javier
Dávila Cansino, José Carlos
Vizuete Chacón, María Luisa
Carmona Cuenca, Irene
Jiménez Muñoz, Sebastián
Trujillo Estrada, Laura Isabel
Sánchez Varo, Raquel María
Torres Canalejo, Manuel
Sánchez Mejías, Elisabeth
Navarro Garrido, Victoria
Departamento: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Fecha: 2012
Publicado en: Molecular Neurodegeneration, 7 (59), 1-15.
Tipo de documento: Artículo
Resumen: Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also proposed that dystrophies might interfere with normal intracellular proteolysis. In this work, we have investigated the progression of the hippocampal pathology and the possible implication in Abeta production in young (6 months) and aged (18 months) PS1(M146L)/APP(751sl) transgenic mice. Results: Our data demonstrated the existence of a progressive, age-dependent, formation of axonal dystrophies, mainly located in contact with congophilic Abeta deposition, which exhibited tau and neurofilament hyperphosphorylation. This progressive pathology was paralleled with decreased expression of the motor proteins kinesin and dynein. Furthermore, we al...
[Ver más]
Tamaño: 2.253Mb
Formato: PDF

URI: http://hdl.handle.net/11441/18243

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivadas 4.0 España

Este registro aparece en las siguientes colecciones