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Presenilin/gamma-secretase regulates neurexin processing at synapses

Opened Access Presenilin/gamma-secretase regulates neurexin processing at synapses
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Autor: Gómez Scholl, Francisco Manuel
Servián Morilla, Emilia
Saura, Carlos A.
Fecha: 2011
Publicado en: PLoS One, 6 (4), e19430-1-e19430-13.
Tipo de documento: Artículo
Resumen: Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during synaptic differentiation. The binding of presynaptic neurexins to postsynaptic partners, such as neuroligins, has been proposed to participate in a signaling pathway that regulates synapse formation/stabilization. The identification of mutations in neurexin genes associated with autism and mental retardation suggests that dysfunction of neurexins may underlie synaptic defects associated with brain disorders. However, the mechanisms that regulate neurexin function at synapses are still unclear. Here, we show that neurexins are proteolytically processed by presenilins (PS), the catalytic components of the c-secretase complex that mediates the intramembraneous cleavage of several type I membrane proteins. Inhibition of PS/c-secretase by using pharmacological and genetic approaches induces a drastic accumulation of neurexin C-terminal fragments (CTFs) in cultured rat hipp...
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Cita: Gómez Scholl, F.M., Servián Morilla, E. y Saura, C.A. (2011). Presenilin/gamma-secretase regulates neurexin processing at synapses. PLoS One, 6 (4), e19430-1-e19430-13.
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