Listar Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) por título
Mostrando ítems 89-108 de 181
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Manganese is a physiologically relevant TORC1 activator in yeast and mammals
(eLife Sciences Publications, 2022)The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...
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Manganese Redistribution by Calcium-stimulated Vesicle Trafficking Bypasses the Need for P-type ATPase Function
(American Society for Biochemistry and Molecular Biology, 2015)Regulation of intracellular ion homeostasis is essential for eukaryotic cell physiology. An example is provided by loss ...
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MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1
(Company of Biologists, 2016)Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the ...
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Metabolic Reprogramming by Acly Inhibition Using SB-204990 Alters Glucoregulation and Modulates Molecular Mechanisms Associated with Aging
(Springer Nature, 2023)ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid ...
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Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence
(Anatomical Society of Great Britain and Ireland, John Wiley & Sons, 2016)Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies ...
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miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
(The American Society of Gene and Cell Therapy, 2018-09-07)Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this ...
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Mitochondrial Factors in the Cell Nucleus
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene ...
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Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...
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Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes
(American Society for Cell Biology, 2017)Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required ...
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
(Cold Spring Harbor Laboratory Press, 2016)Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes ...
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Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
(Nature Publishing Group:, 2018)Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ...
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MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...
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Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance
(Wiley-Blackwell, 2021)DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ...
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Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
(Elsevier, 2015)DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia ...
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NR5A2/LRH-1 Regulates the PTGS2-PGE2-PTGER1 Pathway Contributing to Pancreatic Islet Survival and Function
(Elsevier, 2022)LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets ...
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Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the ...
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Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair
(Oxford University Press, 2018)The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks ...
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Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.
(Nature Research, 2022-10-11)The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...
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Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells
(Springer Nature, 2019-09)Aims/hypothesis: Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical that has been associated with type 2 ...