Listar Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) por título
Mostrando ítems 25-44 de 181
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Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
(Frontiers Media, 2017)In case we needed reminding, age-related neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease ...
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Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
(Oxford University Press, 2013)While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice
(eLife Sciences Publications, 2016)Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms ...
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Crosstalk between chromatin structure, cohesin activity and transcription
(BMC (part of Springer Nature), 2019)Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and ...
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Cryopreservation of GABAergic neuronal precursors for cell-based therapy
(Public Library of Science, 2017)Cryopreservation protocols are essential for stem cells storage in order to apply them in the clinic. Here we describe a ...
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CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response
(Cold Spring Harbor Laboratory Press, 2021)In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular ...
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder
(Elsevier, 2016)From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) ...
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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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Disease-Causing Mutations in BEST1 Gene Are Associated with Altered Sorting of Bestrophin-1 Protein
(MDPI, 2013)Mutations in BEST1 gene, encoding the bestrophin-1 (Best1) protein are associated with macular dystrophies. Best1 is ...
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Distinct responses of human peripheral blood cells to different misfolded protein oligomers
(Wiley-Blackwell, 2021)Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein ...
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Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange
(2012)Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination ...
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Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
(Public Library of Science, 2015)Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular ...
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Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ...
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Editorial: Molecular chaperones and neurodegeneration
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EGF-induced adipose tissue mesothelial cells undergo functional vascular smooth muscle differentiation
(Nature Publishing Group, 2014)Recent studies suggested that the post-natal mesothelium retain differentiative potential of the embryonic mesothelium, ...
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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
(Elsevier, 2019)Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...