Listar Artículos (Fisiología Médica y Biofísica) por título
Mostrando ítems 285-304 de 325
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Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound
(Public Library of Science, 2012-05-18)Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many ...
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Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension
(European Respiratory Society, 2021-03-04)Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...
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Ten simple rules for aspiring graduate students
(Public Library of Science, 2021-08-19)Several supervillains have higher degrees—why don’t you? There can be a variety of reasons for wanting to go to grad school ...
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The Active and Periactive Zone Organization and the Functional Properties of Small and Large Synapses
(2016-05-24)The arrival of an action potential (AP) at a synaptic terminal elicits highly synchronized quanta release. Repetitive APs ...
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The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...
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The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
(Springer, 2018-11-29)Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. ...
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The Childhood-Onset Neurodegeneration with Cerebellar Atrophy (CONDCA) Disease Caused by AGTPBP1 Gene Mutations: The Purkinje Cell Degeneration Mouse as an Animal Model for the Study of this Human Disease
(MDPI, 2021-09-04)Recent reports have identified rare, biallelic damaging variants of the AGTPBP1 gene that cause a novel and documented ...
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The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells
(Frontiers Media, 2022-11-15)Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished ...
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The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses
(Nature Research, 2020-07-21)HERC1 is a ubiquitin ligase protein, which, when mutated, induces several malformations and intellectual disability in ...
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The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGF and Hippo pathways
(OXFORD UNIV PRESS, 2022)High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation ...
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The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release
(Amer Soc Biochemistry Molecular Biology Inc, 2021)Gene duplication generates new functions and traits, enabling evolution. Human-specific duplicated genes in particular are ...
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The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia
(2004)The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the ...
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The mouse levator auris longus muscle: an amenable model system to study the role of postsynaptic proteins to the maintenance and regeneration of the neuromuscular synapse
(Frontiers Media S.A., 2020)The neuromuscular junction (NMJ) is the peripheral synapse that controls the coordinated movement of many organisms. The ...
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The RhoB small GTPase in physiology and disease
(2016-10-23)RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique ...
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The role of non-coding RNAs in autophagy during carcinogenesis
(Frontiers Media S.A., 2022)Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway involved in self-renewal and quality ...
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The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals
(Wiley, 2009-03)We monitored the spatial distribution of exo- and endocytosis at 37◦C in mouse motor nerve terminals expressing synaptopHluorin ...
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The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
(CELL PRESS, 2004-04-22)Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 ...
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The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism
(CINP, 2013)Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described ...