Browsing Artículos (Fisiología Médica y Biofísica) by Title
Now showing items 122-141 of 331
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Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
(Wiley Open Access, 2020)Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...
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Gating of O2-sensitive K + Channels of Arterial Chemoreceptor Cells and Kinetic Modifications Induced by Low PO2
(1992)We have studied the kinetic properties of the O2-sensitive K+ channels (KO2 channels) of dissociated glomus cells from ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
(Wiley, 2017-09)Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ...
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Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors
(WILEY, 2016)Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is ...
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Generation of human organs in pigs via interspecies blastocyst complementation
(Wiley-Blackwell Verlag GmbH, 2016-10-19)More than eighteen years have passed since the first derivation of human embryonic stem cells (ESCs), but their clinical ...
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Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy
(MDPI AG, 2023-03-15)Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. ...
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Genetic divergence and demography of pudu deer (Pudu puda) in five provinces of southern Chile, analyzed through latitudinal and longitudinal ranges
(Pensoft Publishers, 2022)Pudu deer (Pudu puda) is endemic to the temperate rainforests of Chile. Genetic studies at different geographic scales for ...
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Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma
(Oxford University Press, 2020)For decades, it has been known that gliomas follow a non-random spatial distribution, appearing more often in some brain ...
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Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents
(Frontiers Media, 2020)It is well-established that the spread of many multidrug-resistant (MDR) bacteria is predominantly clonal. Interestingly ...
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Glucose sensing by carotid body glomus cells: potential implications in disease
(Frontiers Media, 2014-10-15)The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
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Grey and white matter microstructure is associated with polygenic risk for schizophrenia
(Nature Publishing Group, 2021-08-30)Recent discovery of approximately 270 common genetic variants associated with schizophrenia has enabled polygenic risk ...
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Hepatocellular carcinoma risk-stratification based on ASGR1 in circulating epithelial cells for cancer interception
(Frontiers, 2022-11-28)Purpose: Lack of diagnostic and prognostic biomarkers in hepatocellular carcinoma impedes stratifying patients based on ...
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Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages
(NATURE PUBLISHING GROUP, 2021-07-22)Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 ...
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HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018-04-19)Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks
(Elsevier, 2023)Though the lateral frontal cortex is broadly implicated in cognitive control, functional MRI (fMRI) studies suggest ...
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Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
(Springer Nature, 2022)Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, ...
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Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
(Springer, 2021)Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
(1994)We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ...
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Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain
(1997)The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. ...
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IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner
(Willey, 2022)Insulin-like growth factor-I (IGF-I) signaling plays a key role in neuroinflammation. Here we show that IGF-1 also regulates ...