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Listar Artículos (Química Orgánica) por autor "Nanba, Eiji"
Mostrando ítems 1-7 de 7
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Artículo
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
Fuente, Alex de la; Rísquez Cuadro, Rocio; Verdaguer, Xavier; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen; Riera, Antoni (Elsevier, 2016)Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ...
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Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators
González Cuesta, Manuel; Goyard, David; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Renaudet, Olivier; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2019)Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ...
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Pharmacological Chaperones for the Treatment of α-Mannosidosis
Rísquez Cuadro, Rocío; Matsumoto, Reimi; Ortega Caballero, Fernando; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation ...
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
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Structural basis of pharmacological chaperoning for human β-galactosidase
Suzuki, Hironori; Ohto, Umeharu; Higaki, Katsumi; Mena Barragán, Teresa; Aguilar Moncayo, Matilde; Ortiz Mellet, Carmen; Nanba, Eiji; García Fernández, José Manuel; Suzuki, Yoshiyuki; Shimizu, Toshiyuki (Elsevier, 2014)GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal β-galactosidase ...