Listar Artículos (Química Orgánica) por título
Mostrando ítems 191-210 de 267
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Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Even though general improvement of quality of life has happened around the globe, statistics show that gastric cancer is ...
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Selenium and sulphur derivatives of hydroxytyrosol: inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats
(Springer Nature, 2019)Purpose: The objective of this study was to evaluate the capacity of modified phenols synthesized from hydroxytyrosol, a ...
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Selenium and Sulphur Derivatives of Hydroxytyrosol: Inhibition of Lipid Peroxidation in Liver Microsomes of Vitamin E-deficient Rats
(Springer Nature, 2019)Purpose: The objective of this study was to evaluate the capacity of modified phenols synthesized from hydroxytyrosol, a ...
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Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
(Elsevier, 2019-10-01)Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin ...
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Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity
(American Society for Biochemistry and Molecular Biology Inc., 2021)Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in ...
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Self-association of a naphthalene-capped-β-cyclodextrin through cooperative strong hydrophobic interactions
(Elsevier, 2011-09-05)NMR, circular dichroism and fluorescence techniques were used to study the structure in solution of a new β-cyclodextrin ...
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Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma
(American Chemical Society, 2023)Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...
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Silver-free gold-catalyzed heterocyclizations through intermolecular H-bonding activation.
(AMER Chemical Soc, 2023-01-27)Modulable monosulfonyl squaramides have been shown to exert activation of gold(I) chloride complexes through H-bonding in ...
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Sinorhizobium fredii HH103 invades lotus burttii by crack entry in a nod factor- and surface polysaccharide-dependent manner
(American Phytopathological Society, 2016)Sinorhizobium fredii HH103-Rifr, a broad host range rhizobial strain, induces nitrogen-fixing nodules in Lotus burttii but ...
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Solvent-free synthesis of quaternary alpha-hydroxy alpha-trifluoromethyl diazenes: the key step of a nucleophilic formylation strategy
(Royal Society of Chemistry, 2016)An efficient, scalable and operationally simple one-pot, 2-step strategy for the nucleophilic formylation of trifluoromethyl ...
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sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors
(Elsevier, 2024)The conventional approach to developing light-sensitive glycosidase activity regulators, involving the combination of a ...
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sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
(Elsevier, 2019)Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ...
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
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Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides
(2007)The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ...
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Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions
(SAGE Publications, 2019)Fluid biphasic systems are one of the most interesting dynamic systems in chemistry and biochemistry. In nuclear magnetic ...
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Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
(American Chemical Society, 2024-01-02)STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small ...
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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ...
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Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
(Wiley-Blackwell, 2020)An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ...
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Stereoselective enzymatic reduction of 1,4-diaryl-1,4-diones to the corresponding diols employing alcohol dehydrogenases
(MDPI, 2018)Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral 1,4-diaryl-1,4-diols through the ...
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Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
(Royal Society of Chemistry, 2015)2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ...