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Listar Artículos (Genética) por autor "Valle Rosado, Iván"
Mostrando ítems 1-12 de 12
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A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae
Rodríguez Galán, Olga; García Gómez, Juan José; Valle Rosado, Iván; Wei, Wu; Méndez-Godoy, Alfonso; Pillet, Benjamin; Alekseenko, Alisa; Steinmetz, Lars M.; Pelechano, Vicent; Kressler, Dieter; Cruz Díaz, Jesús de la (Oxford University Press, 2021)Proteostasis needs to be tightly controlled to meet the cellular demand for correctly de novo folded proteins and to avoid ...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
Medrano, M.; Contreras, M.; Caballero Velázquez, Teresa; Martínez, L.; Bejarano-García, J. A.; Calderón Ruiz, Rocío; García-Calderón, C. B.; Valle Rosado, Iván; Pérez Simón, José Antonio (Nature Publishing Group, 2024)BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is ...
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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Pontel, Lucas B.; Valle Rosado, Iván; Burgos Barragán, Guillermo; Garaycoechea, Juan I.; Yu, Rui; Arends, Mark J.; Patel, Ketan J. (Cell Press, 2015)Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA ...
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FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine
Peña Gómez, Mª José; Moreno Gordillo, Paula; Narmonté, Milda; García Calderón, Clara Beatriz; Ruksenaité, Audronė; Klimašauskas, Saulius; Valle Rosado, Iván (Springer Nature, 2022)Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly ...
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Final pre-40s maturation depends on the functional integrity of the 60s subunit ribosomal protein l3
García Gómez, Juan José; Fernández Pevida, Antonio; Lebaron, Simon; Valle Rosado, Iván; Tollervey, David W.; Kressler, Dieter; Cruz Díaz, Jesús de la (Public Library of Science, 2014)Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. ...
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Fluorescent calixarene-schiff as a nanovehicle with biomedical purposes
Lebrón Romero, José Antonio; Moyá Morán, María Luisa; López López, Manuel; Deasy, M.; Muñoz Wic, Ana; García Calderón, Clara Beatriz; Valle Rosado, Iván; Bernal Pérez, Eva; Ostos Marcos, Francisco José; López-Cornejo, María del Pilar (Multidisciplinary Digital Publishing Institute (MDPI), 2022-07-14)Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have ...
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Functional analysis of saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis
Valle Rosado, Iván; Kressler, Dieter; Cruz Díaz, Jesús de la (Oxford University Press, 2007)Ribosome synthesis in eukaryotes requires a multitude oftrans-acting factors. These factors act at many steps as the ...
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Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery
Lebrón Romero, José Antonio; López López, Manuel; García Calderón, Clara Beatriz; Valle Rosado, Iván; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Rodik, Roman V; Kalchenko, Vitaly I.; Bernal Pérez, Eva; Moyá Morán, María Luisa; López-Cornejo, María del Pilar; Ostos Marcos, Francisco José (MDPI, 2021-08)The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried ...
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Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
Valle Rosado, Iván; Cruz Díaz, Jesús de la (Cold Spring Harbor Laboratory Press, 2004)Ribosome biogenesis requires > 100 nonribosomal proteins, which are associated with different preribosomal particles. The ...
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Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
Bejarano García, José Antonio; Millán-Uclés, África; Valle Rosado, Iván; Sánchez Abarca, Luis Ignacio; Caballero Velázquez, Teresa; Durán Galván, María José; Pérez Simón, José Antonio; Piraut Palomo, José Ignacio (2016)It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to ...
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Artículo
Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium
Pontel, Lucas B.; Langenick, Judith; Valle Rosado, Iván; Zhang, Xiao-Yin; Traynor, David; Kay, Robert R.; Patel, Ketan J. (The Company of Biologists, 2016)As time passes, mutations accumulate in the genomes of all living organisms. These changes promote genetic diversity, but ...
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XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
Peña Gómez, Mª José; Suárez Pizarro, Marina; Valle Rosado, Iván (MDPI, 2022)Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution ...