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dc.creatorNepravishta, Ridvanes
dc.creatorMonaco, Serenaes
dc.creatorMuñoz García, Juan Carloses
dc.creatorKhimyak, Yaroslav Z.es
dc.creatorAngulo Álvarez, Jesúses
dc.date.accessioned2020-06-09T09:13:29Z
dc.date.available2020-06-09T09:13:29Z
dc.date.issued2019
dc.identifier.citationNepravishta, R., Monaco, S., Muñoz García, J.C., Khimyak, Y.Z. y Angulo Álvarez, J. (2019). Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions. Natural Product Communications, 14 (5), 1-6.
dc.identifier.issn1934-578X (impreso)es
dc.identifier.issn1555-9475 (electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/97564
dc.description.abstractFluid biphasic systems are one of the most interesting dynamic systems in chemistry and biochemistry. In nuclear magnetic resonance (NMR) spectroscopy, the study of the solute dynamics across fluid biphasic systems requires the introduction of dedicated NMR methods, due to their intrinsic heterogeneity. Diffusion and spatially resolved NMR techniques represent a useful approach for dealing with the study of solutes in biphasic systems and have been applied lately with success. Nevertheless, other potential applications of NMR spectroscopy for biphasic systems remain to be explored. In this proof of-concept communication, we specifically aimed to investigate whether solute exchange between two immiscible phases can be followed by NMR experiments involving transfer of magnetization. To that aim, we have used spatially resolved saturation transfer difference NMR (SR-STD NMR) experiments to analyze solute exchange by transfer of saturation from one phase to the other in a biphasic system and have explored which are the underlying mechanisms leading to the transfer of magnetization between phases and the limits of the approach. We hereby demonstrate that SR-STD NMR is feasible and that it might be implemented in pharmacological screening for binders of biological receptors or in the study of chemical and biochemical reactions occurring at interfaces.es
dc.formatapplication/pdfes
dc.format.extent6 p.es
dc.language.isoenges
dc.publisherSAGE Publicationses
dc.relation.ispartofNatural Product Communications, 14 (5), 1-6.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSR-STD NMRes
dc.subjectBiphasic systemes
dc.subjectCESTes
dc.subject1 H-NMRes
dc.subjectInterfacees
dc.titleSpatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactionses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.publisherversionhttps://doi.org/10.1177/1934578X19849789es
dc.identifier.doi10.1177/1934578X19849789es
dc.journaltitleNatural Product Communicationses
dc.publication.volumen14es
dc.publication.issue5es
dc.publication.initialPage1es
dc.publication.endPage6es

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